Prevalence of Human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil
| Autor: | Jaila Dias Borges Lalwani, Cynara Melo Gato, Cristóvão Alves da Costa, Lucinei Alves Maciel, Márcia Poinho EncarnaçÃo de Morais, Pritesh Lalwani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Enzyme-linked Immunosorbent Assay Cross-sectional study viruses Htlv-1 Infection Prevalence Seroprevalence Human T-lymphotropic virus 0302 clinical medicine Seroepidemiologic Studies immune system diseases hemic and lymphatic diseases Prevalence of HTLV Epidemiology Medicine Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Human T-lymphotropic virus 1 Htlv-2 Infection biology Isolation And Purification Human T-lymphotropic virus 2 virus diseases Middle Aged Epidemiology of HTLV infection Female Original Article Antibody Primate T-lymphotropic Virus 2 T-lymphotropic virus type 1 and 2 Brazil Human Adult medicine.medical_specialty Western Blotting lcsh:Arctic medicine. Tropical medicine Adolescent lcsh:RC955-962 030231 tropical medicine Major Clinical Study Blotting Western Enzyme-Linked Immunosorbent Assay Blood donors Cross-sectional Studies 03 medical and health sciences Young Adult Virology Structured Questionnaire Statistics And Numerical Data Humans Seroepidemiology business.industry Blood Donor Brasil Social Status HTLV biology.organism_classification Htlv-ii Infections HTLV-I Infections 030104 developmental biology Cross-Sectional Studies HTLV-II Infections biology.protein Cross-sectional Study business HTLV subtyping HTLV1 HTLV2 |
| Zdroj: | Revista do Instituto de Medicina Tropical de São Paulo, Vol 59, Iss 0 (2017) Revista do Instituto de Medicina Tropical de São Paulo Revista do Instituto de Medicina Tropical de São Paulo; Vol. 59 (2017); e80 Revista do Instituto de Medicina Tropical de São Paulo; v. 59 (2017); e80 Instituto de Medicina Tropical (IMT) instacron:IMT Revista do Instituto de Medicina Tropical de São Paulo, Volume: 59, Article number: e80, Published: 21 DEC 2017 Repositório Institucional do INPA Instituto Nacional de Pesquisas da Amazônia (INPA) instacron:INPA |
| ISSN: | 1678-9946 0036-4665 |
| Popis: | Introduction: Human T-lymphotropic virus type 1 and 2 (HTLV-1/2) is endemic in Brazil, but few studies have investigated the seroprevalence of HTLV and its subtypes among blood donors in the capital city Manaus, Amazonas State, Brazil. Aim: To estimate the seroprevalence of HTLV-1/2 and to identify circulating subtypes among blood donors in Manaus. Materials and Methods: Blood donors (2001-2003) were screened for HTLV-1/2 antibodies by ELISA. Positive results were confirmed and subtyped by Western blot assays. Prevalence rates were calculated and compared with demographic data. Results: Among the 87,402 individuals screened, 116 (0.13%) were seropositive for HTLV-1/2. A second sample (76/116) was collected and retested by HTLV-1/2 ELISA, of which only 41/76 were positive. Western blot confirmed HTLV infection in 24/41 retested blood donors [HTLV-1 (n=16), HTLV-2 (n=5) and HTLV-untypable (n=3)]. Discussion: HTLV-1 and HTLV-2 are prevalent among blood donors in Manaus. However, additional studies are needed to comprehend the epidemiology of HTLV-1/2 in Amazonas not only to understand the pathophysiology of the disease providing adequate medical assistance, but also to reduce or block virus transmission. © 2017, Instituto de Medicina Tropical de Sao Paulo. All rights reserved. |
| Databáze: | OpenAIRE |
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