Pandemic potential of avian influenza A (H7N9) viruses
| Autor: | Shinji Watanabe, Gabriele Neumann, Eileen A. Maher, Yoshihiro Kawaoka, Tokiko Watanabe |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
China Guinea Pigs Biology medicine.disease_cause Influenza A Virus H7N9 Subtype Microbiology H5N1 genetic structure Article Birds Orthomyxoviridae Infections Virology Zoonoses Pandemic Influenza Human medicine Influenza A virus Disease Transmission Infectious Animals Humans Human virome Pandemics Transmission (medicine) Ferrets Influenza A virus subtype H5N1 Infectious Diseases Influenza in Birds Disease transmission |
| Zdroj: | Trends in microbiology. 22(11) |
| ISSN: | 1878-4380 |
| Popis: | Avian influenza viruses rarely infect humans, but the recently emerged avian H7N9 influenza viruses have caused sporadic infections in humans in China, resulting in 440 confirmed cases with 122 fatalities as of 16 May 2014. In addition, epidemiologic surveys suggest that there have been asymptomatic or mild human infections with H7N9 viruses. These viruses replicate efficiently in mammals, show limited transmissibility in ferrets and guinea pigs, and possess mammalian-adapting amino acid changes that likely contribute to their ability to infect mammals. In this review, we summarize the characteristic features of the novel H7N9 viruses and assess their pandemic potential. |
| Databáze: | OpenAIRE |
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