The impact of the largest metastasis size on nodal tumor burden in colorectal carcinomas: implications for the sentinel lymph node theory in cancers of the large intestine
| Autor: | Gábor Cserni, Kornél Vajda, Vincent Vinh-Hung, Mihály Svébis, Rita Bori |
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| Přispěvatelé: | Medical Imaging and Physical Sciences |
| Rok vydání: | 2007 |
| Předmět: |
Male
Oncology medicine.medical_specialty Colorectal cancer Sentinel lymph node Tumor burden Metastasis Internal medicine Biopsy Humans Medicine Large intestine Intestine Large Aged medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry General Medicine Middle Aged medicine.disease Primary tumor Tumor Burden medicine.anatomical_structure Lymphatic Metastasis Lymph Node Excision Female Surgery Lymph Nodes Colorectal Neoplasms business NODAL |
| Zdroj: | Vrije Universiteit Brussel |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.20725 |
| Popis: | Background and Objectives Successful sentinel lymph node (SLN) biopsy has been reported in colorectal cancer (CRC), but its results are still controversial. The SLN theory suggests that there is an orderly spread from the primary tumor to the SLNs first, and from the SLNs to further nodes later. This study examines the influence of nodal metastasis size on further nodal involvement. Methods CRC resection specimens with nodal metastasis have been evaluated for the maximum nodal metastasis size for a period of 5 years. All lymph nodes (LNs) were submitted to standard histological examination. Results Two hundred thirty-five CRC specimens with a single invasive tumor were assessed. The mean numbers of LNs examined and involved were 18 and 4, respectively. The largest metastasis size ranged from 0.14 to 22.1 mm. There was a significant correlation between this parameter and the number or the ratio of LNs involved (Spearman's Rho: 0.517, and 0.382, respectively; P |
| Databáze: | OpenAIRE |
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