Evaluation of laminin peptide fragments labeled with indium-111 for the potential imaging of malignant tumors
| Autor: | M. L. Brown, S. S. Jonnalagadda, M. W. Epperly, M. Mokotoff, D. P. Swanson |
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| Rok vydání: | 1997 |
| Předmět: |
Negative control
Peptide Biochemistry chemistry.chemical_compound Mice Endocrinology Laminin Peptide synthesis Animals Tissue Distribution Tissue distribution Amino Acid Sequence Receptor Laminin receptor Radionuclide Imaging Peptide sequence chemistry.chemical_classification Mice Inbred C3H biology Indium Radioisotopes Mammary Neoplasms Experimental Molecular biology Peptide Fragments Disease Models Animal chemistry cardiovascular system biology.protein Female circulatory and respiratory physiology |
| Zdroj: | The journal of peptide research : official journal of the American Peptide Society. 49(6) |
| ISSN: | 1397-002X |
| Popis: | The laminin peptide fragments GYIGSR-NH2 and CDPGYIGSR-NH2 are known to bind to a 67-kDa laminin receptor. This receptors is understood to be expressed at higher than normal levels in malignant tumor cells, particularly those of breast and colon carcinomas. Peptides DTPA-GYIGSR-NH2 (1), DTPA-(GYIGSR-NH2)2 (2), DTPA-CDPGYIGSR-NH2 (3), DTPA-(CDPGYIGSR-NH2)2 (4), and negative control DTPA-GAGAGA-NH2 (5) were prepared by solid-phase peptide synthesis. All five DTPA-conjugated peptides were subsequently radiolabeled with 111In and their tissue distribution evaluated in mice bearing C3H tumors. 111In-3 and 111In-4 showed the highest specific tumor localization. These preliminary data support further study of radiolabeled petide fragments for the potential detection of malignant tumors of the breast and other organs. |
| Databáze: | OpenAIRE |
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