Relationship between HLA antigens and infectious agents in contributing towards the development of Graves' disease
| Autor: | Eduardo Antônio Donadi, M.H.S. Kraemer, Luiz Alberto Magna, M. A. Tambascia, L. S. Prigenzi |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male endocrine system diseases Adolescent Graves' disease Immunology Human leukocyte antigen Cross Reactions medicine.disease_cause Antibodies Viral Serology HLA-DR3 Antigen Antigen Gene Frequency HLA Antigens medicine Humans Coxsackie B virus Yersinia enterocolitica Alleles Autoantibodies biology business.industry General Medicine Middle Aged medicine.disease biology.organism_classification Cytotoxicity Tests Immunologic Virology Antibodies Bacterial Thyroid disorder Graves Disease Enterovirus B Human biology.protein Female Antibody business |
| Zdroj: | Immunological investigations. 27(1-2) |
| ISSN: | 0882-0139 |
| Popis: | Graves' disease (GD) is an autoimmune thyroid disorder which is associated with the human leucocyte antigens HLA-DR3 and DQA1* O501 in Caucasians. We have explored the possibility that some patients with certain HLA specificities develop anti-HLA antibodies which are correlated with environmental factors that may contribute to the development of GD. We studied 40 GD patients and 157 healthy individuals (controls). Serology was used to type HLA-A, -B, -Cw, and -DR antigens. The frequencies of these antigens in relation to lymphocytotoxic anti-HLA-A-B-Cw-DR antibodies and two environmental factors (Yersinia enterocolitica and Coxsackie B virus) were determined. The frequencies of HLA-B15, -B21 and DR3 antigens were increased, whereas HLA-DR5 antigen was decreased in GD patients. A significant association between HLA-DR3 antigen and lymphocytotoxic antibodies was observed, i.e., IgGs from GD patients were cytotoxic to HLA-DR3+ normal B cells. Following absorption with Yersinia enterocolitica or Coxsackie-B-virus, only Coxsackie-B virus completely inhibited the lymphocytotoxic reactions against HLA-DR3+ B cells. Besides confirming the association of HLA-DR3 with GD, this study also suggests the role of Coxsackie-reactive HLA-DR3 antibodies as contributing factors to the pathogenesis of the disease. |
| Databáze: | OpenAIRE |
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