FT-IR and X-ray spectroscopic investigations of Na-diclofenac-cyclodextrins interactions
| Autor: | Ioan Bratu, J. P. Huvenne, Emil Indrea, Corina Ionesc, P. Legrand, S. Astilean |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Cyclodextrins
Drug Carriers Diclofenac Chemistry Macromolecular Substances Anti-Inflammatory Agents Non-Steroidal Infrared spectroscopy Crystal structure Atomic and Molecular Physics and Optics Analytical Chemistry Adduct Crystallography Acetic acid chemistry.chemical_compound Pyranose X-Ray Diffraction X-ray crystallography Spectroscopy Fourier Transform Infrared Molecule Humans Drug Interactions Drug carrier Instrumentation Spectroscopy |
| Zdroj: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (1) |
| ISSN: | 1386-1425 |
| Popis: | Diclofenac-Na (DCF-Na, i.e. the salt of the 2-[(2,6-dichlorophenyl)amino]-phenyl- acetic acid) is a common nonsteroidic anti inflammatory from the group of the arylalcanoic acid derivatives and with large therapeutic applicability in the symptomatic standard treatment of the rheumatic affections. Due to the structural particularities, the cyclodextrins-thoroidal oligosacharides-relatively hydrophobes produce the inclusion complexes or adducts in which the “host” molecules (cyclodextrins, CD) includes spatially the “guest” molecule (the drug molecule). The association of DCF-Na with β — CD in some therapeutic formulas can contribute to the optimization of his physical-chemical and pharmaceutical properties. The compatibility of DCF with β — CD and the appearance of inclusion complexes represents the objective of some studies. New data on the synthesis and X- ray crystal structure of β — CD/DCF - Na undecahydrate with a unique packing arrangement were recently published[1]. The results obtained using IR spectroscopy and X-ray diffraction applied to β — CD/DCF — Na systems are presented here. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect