| Autor: |
Chiang-Wen Lee, Lee-Fen Hsu, I.-Lin Wu, Yung-Li Wang, Wei-Chen Chen, Yan-Jun Liu, Lu-Tang Yang, Chong-Lun Tan, Yueh-Hsia Luo, Chia-Ching Wang, Hui-Wen Chiu, Thomas Chung-Kuang Yang, Yen-Yue Lin, Hsin-An Chang, Yao-Chang Chiang, Ching-Hsiang Chen, Ming-Hsueh Lee, Kuo-Ti Peng, Cathy Chia-Yu Huang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Hazardous Materials. 430:128431 |
| ISSN: |
0304-3894 |
| Popis: |
Microplastics (MPs) pollution has become a serious environmental issue worldwide, but its potential effects on health remain unknown. The administration of polystyrene MPs (PS-MPs) to mice for eight weeks impaired learning and memory behavior. PS-MPs were detected in the brain especially in the hippocampus of these mice. Concurrently, the hippocampus had decreased levels of immediate-early genes, aberrantly enhanced synaptic glutamate AMPA receptors, and elevated neuroinflammation, all of which are critical for synaptic plasticity and memory. Interestingly, ablation of the vagus nerve, a modulator of the gut-brain axis, improved the memory function of PS-MPs mice. These results indicate that exposure to PS-MPs in mice alters the expression of neuronal activity-dependent genes and synaptic proteins, and increases neuroinflammation in the hippocampus, subsequently causing behavioral changes through the vagus nerve-dependent pathway. Our findings shed light on the adverse impacts of PS-MPs on the brain and hippocampal learning and memory. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect