Modeling of Drug Delivery by A Pump Driven Micro-Needle Array System
| Autor: | Zhi Gang Feng, Min Pan, Kai Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Jet (fluid) Work (thermodynamics) Materials science Flow (psychology) Drug delivery system Biomedical Engineering Medicine (miscellaneous) Boundary (topology) Bioengineering 02 engineering and technology Mechanics Radius infusion flow 021001 nanoscience & nanotechnology Article Volumetric flow rate 03 medical and health sciences 030104 developmental biology micro-needle fluid infusion Diffusion (business) 0210 nano-technology Material properties |
| Zdroj: | The Open Biomedical Engineering Journal |
| ISSN: | 1874-1207 |
| Popis: | Background: Micro-needles were proposed as one of the alternatives to deliver drugs painlessly passing through stratum corneum in recent years. In this work, a mathematical model is presented to characterize the in fusion flow of a hollow micro-needle array driven by a micro-pump. Methods: By assuming the injection of each micro-needle undergoes a spherical expansion and diffusion, the model is able to calculate the time-varying expansion radius, and the diffusion boundary, provided that the material properties and the micro-needle system parameters are known. Results and Conclusion: The calculation results show that the expansion caused by the infusion of micro-needles stops and the flow rate drops to zero in a short time. However, the diffusion boundary is much bigger than the expansion and the infusion continues if the surrounding material is absorptive. The experimental results of jet infusion through a single needle in silicon rubber and polyacrylamide gel agree with the calculation results qualitatively. |
| Databáze: | OpenAIRE |
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