Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer
| Autor: | Marie Tosolini, Matilde Todaro, Serena Meraviglia, Giorgio Stassi, Salvatore Vieni, Francesco Dieli, Veronica Catalano, C. La Mendola, E. Lo Presti, Giuseppe Cicero, Valentina Orlando, Jean-Jacques Fournié |
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| Přispěvatelé: | Meraviglia, S., LO PRESTI, E., Tosolini, M., LA MENDOLA, C., Orlando, V., Todaro, M., Catalano, V., Stassi, G., Cicero, G., Vieni, S., Fourniã, J., Dieli, F. |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy colon cancer DFS IFN-g TILs gd T cells Immunology and Allergy Immunology Oncology Colorectal cancer Biology ifn-γ tils lcsh:RC254-282 03 medical and health sciences medicine Cytotoxic T cell Original Research Settore MED/04 - Patologia Generale γδ t cells Cancer gd T cell TIL medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology Tumor progression lcsh:RC581-607 |
| Zdroj: | OncoImmunology, Vol 6, Iss 10 (2017) |
| ISSN: | 2162-4011 |
| Popis: | γδ T cells usually infiltrate many different types of cancer, but it is unclear whether they inhibit or promote tumor progression. Moreover, properties of tumor-infiltrating γδ T cells and those in the corresponding normal tissue remain largely unknown. Here we have studied features of γδ T cells in colorectal cancer, normal colon tissue and peripheral blood, and correlated their levels with clinicopathologic hallmarks. Flow cytometry and transcriptome analyses showed that the tumor comprised a highly variable rate of TILs (5–90%) and 4% γδ T cells on average, with the majority expressing Vδ1. Most Vδ1 and Vδ2 T cells showed a predominant effector memory phenotype and had reduced production of IFN- γ which was likely due to yet unidentified inhibitory molecules present in cancer stem cell secretome. Transcriptome analyses revealed that patients containing abundant γδ T cells had significantly longer 5-year disease free survival rate, suggesting their efficacy in controlling tumor at very early stage. |
| Databáze: | OpenAIRE |
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