Pretransplant BK Virus-Specific T-Cell-Mediated Immunity and Serotype Specific Antibodies May Have Utility in Identifying Patients at Risk of BK Virus-Associated Haemorrhagic Cystitis after Allogeneic HSCT
| Autor: | Viera Ludvíková, Marie Kroutilová, Eva Hamsikova, Petr Hubacek, Petr Hainz, Jan Musil, Vojtěch Šroller, Jitka Krystofova, Pavla Pecherková, Jan Vydra, Martina Salakova, Markéta Šťastná-Marková, Šárka Němečková |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
LTag
Urinary system Immunology Disease medicine.disease_cause Asymptomatic Article Virus human BK polyomavirus 1 and 4 (BKPyV 1 and 4) Antigen Immunity Drug Discovery Medicine Pharmacology (medical) haemorrhagic cystitis Pharmacology business.industry hemopoietic stem cell transplantation VP1 anti/BKPyV IgG BK virus Transplantation Infectious Diseases T-cell response immunocompromised patients medicine.symptom business |
| Zdroj: | Vaccines, Vol 9, Iss 1226, p 1226 (2021) Vaccines Volume 9 Issue 11 |
| Popis: | BK polyomavirus (BKPyV) persists lifelong in renal and urothelial cells with asymptomatic urinary shedding in healthy individuals. In some immunocompromised persons after transplantation of hematopoietic stem cells (HSCT), the BKPyV high-rate replication is associated with haemorrhagic cystitis (HC). We tested whether the status of BKPyV immunity prior to HSCT could provide evidence for the BKPyV tendency to reactivate. We have shown that measurement of pretransplant anti-BKPyV 1 and 4 IgG levels can be used to evaluate the HC risk. Patients with anti-BKPyV IgG in the range of the 1st–2nd quartile of positive values and with positive clinical risk markers have a significantly increased HC risk, in comparison to the reference group of patients with “non-reactive” anti-BKPyV IgG levels and with low clinical risk (LCR) (p = 0.0009). The predictive value of pretransplant BKPyV-specific IgG was confirmed by determination of genotypes of the shed virus. A positive predictive value was also found for pretransplant T-cell immunity to the BKPyV antigen VP1 because the magnitude of IFN-γ T-cell response inversely correlated with posttransplant DNAuria and with HC. Our novel data suggest that specific T-cells control BKPyV latency before HSCT, and in this way may influence BKPyV reactivation after HSCT. Our study has shown that prediction using a combination of clinical and immunological pretransplant risk factors can help early identification of HSCT recipients at high risk of BKPyV disease. |
| Databáze: | OpenAIRE |
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