Effect of a marathon run on serum lipoproteins, creatine kinase, and lactate dehydrogenase in recreational runners
| Autor: | Yoshio Kobayashi, Toshiko Takeuchi, Hidekiyo Yoshizaki, Teruo Hosoi, Jack A. Loeppky |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Lipoproteins Physical Therapy Sports Therapy and Rehabilitation Hematocrit Fatty Acids Nonesterified Running chemistry.chemical_compound Reference Values Lactate dehydrogenase Internal medicine Medicine Humans Orthopedics and Sports Medicine Exercise physiology Muscle Skeletal Creatine Kinase Triglyceride biology medicine.diagnostic_test L-Lactate Dehydrogenase business.industry Cholesterol General Medicine Metabolism Endocrinology chemistry Nephrology biology.protein Physical Endurance lipids (amino acids peptides and proteins) Creatine kinase business Lipoprotein |
| Zdroj: | Research quarterly for exercise and sport. 76(4) |
| ISSN: | 0270-1367 |
| Popis: | The objective of this study was to determine the effect of a marathon run on serum lipid and lipoprotein concentrations and serum muscle enzyme activities and follow their recovery after the run. These blood concentrations were measured before, immediately after, and serially after a marathon run in 15 male recreational runners. The triglyceride level was significantly elevated postrace, then fell 30% below baseline 1 day after the run, and returned to baseline after 1 week. Total cholesterol responded less dramatically but with a similar pattern. High-density lipoprotein cholesterol remained significantly elevated and low-density lipoprotein cholesterol was transiently reduced for 3 days after the run. The total cholesterol/high-density cholesterol ratio was significantly lowered for 3 days. Serum lactate dehydrogenase activity significantly doubled postrace and then declined but remained elevated for 2 weeks. Serum creatine kinase activity peaked 24 hr after the run, with a 15-fold rise, and returned to baseline after 1 week. The rise of these enzymes reflects mechanically damaged muscle cells leaking contents into the interstitial fluid. It is concluded that a prolonged strenuous exercise bout in recreational runners, such as a marathon, produces beneficial changes in lipid blood profiles that are significant for only 3 days. However, muscle damage is also evident for 1 week or more from the dramatic and long-lasting effect on enzyme levels. Laboratory values for these runners were outside normal ranges for some days after the race. |
| Databáze: | OpenAIRE |
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