Design and preparation of a novel colon-targeted tablet of hydrocortisone

Autor: Yachao Ren, Shuman Yang, Lei Jiang, Haisheng Peng, Dandan Hu, Hui Yu, Sainan Gao, Wenbin Mao, Yulong Zhou, Jie Hu
Jazyk: angličtina
Rok vydání: 2017
Předmět:
food.ingredient
Materials science
Scanning electron microscope
Composite number
Chitosan/evaluation
lcsh:RS1-441
02 engineering and technology
030226 pharmacology & pharmacy
Gelatin
lcsh:Pharmacy and materia medica
Chitosan
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
food
Differential scanning calorimetry
Fármacos/sistema de liberação/dirigido ao cólon
medicine
Comprimidos/revestidos com bicamada
General Pharmacology
Toxicology and Pharmaceutics
Fourier transform infrared spectroscopy
Chitosan/multilayer coating system/drugs coating
technology
industry
and agriculture
Drugs/administration
Tablets/bilayer-coated
Drugs/delivery system/Colon-targeting
021001 nanoscience & nanotechnology
Quitosana/sistema multicamadas de revestimento/revestimento de fármacos
Quitosana/filme de complexo de gelatina
chemistry
Chemical engineering
Chistosan/evaluation/gelatin complex film
030220 oncology & carcinogenesis
Drugs/delivery system/colon-targeted
Drug delivery
Swelling
medicine.symptom
0210 nano-technology
Chitosan/gelatin complex film/drugs coating
Zdroj: Brazilian Journal of Pharmaceutical Sciences, Volume: 53, Issue: 1, Article number: e15009, Published: 20 APR 2017
Brazilian Journal of Pharmaceutical Sciences; Vol. 52 No. 2 (2016); 239-250
Brazilian Journal of Pharmaceutical Sciences; Vol. 52 Núm. 2 (2016); 239-250
Brazilian Journal of Pharmaceutical Sciences; v. 52 n. 2 (2016); 239-250
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Pharmaceutical Sciences, Vol 53, Iss 1 (2017)
Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 1 (2017); e15009
Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 1 (2017); e15009
Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 1 (2017); e15009
Brazilian Journal of Pharmaceutical Sciences, Volume: 52, Issue: 2, Pages: 239-250, Published: JUN 2016
Brazilian Journal of Pharmaceutical Sciences, Vol 52, Iss 2, Pp 239-250
ISSN: 2175-9790
1984-8250
Popis: The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier transform infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning electron microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were jointly reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit- and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24 h. Overall, colon-targeted drug delivery was achieved by using a chitosan/gelatin complex film and a multilayer coating system. RESUMO O objetivo desta pesquisa foi planejar um novo sistema de liberação de fármacos direcionado ao cólon, utilizando quitosana. Estudaram-se as propriedades dos filmes a fim de obter informações úteis sobre a aplicação desses filmes compósitos. Utilizaram-se os filmes compósitos em sistema de bicamada para investigar a sua viabilidade como materiais de revestimento. Estudos de resistência à tração, grau de intumescimento, solubilidade, grau de biodegradação, no infravermelho por transformada de Fourier (FTIR), de calorimetria diferencial de varredura (DSC) e de microscopia eletrônica de varredura (SEM) mostraram que o filme compósito se formou quando a quitosana e a gelatina reagiram entre si. Os resultados mostraram que a mistura de proporção ótima foi de 6:4 de quitosana:gelatina. Resultados da liberação do fármaco in vitro indicaram que o sistema de revestimento de Eudragit e bicamada de quitosana/gelatina impediu a liberação de fármaco em fluido intestinal simulado (SIF) e em fluido gástrico simulado (SGF). Entretanto, a liberação de fármaco do comprimido revestido em bicamada no SCF aumentou ao longo do tempo e o fármaco foi quase completamente liberado após 24 h. Em geral, se obteve a forma de liberação dirigida ao cólon, utilizando filme complexo de quitosana/gelatina e sistema de revestimento multicamada.
Databáze: OpenAIRE
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