Quality of Life and Voice Changes After a Single Injection in Patients With ADSD Over Time
| Autor: | Meysam Asgari, Farhad Torabinezhad, Payman Dabirmoghaddam, Jamileh Abolghasemi, Maryam Faham, Mohammad Kamali, Thomas Murry |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Longitudinal study medicine.medical_specialty Botulinum Toxins Time Factors Voice Quality Acetylcholine Release Inhibitors Vocal Cords Audiology Injections 030507 speech-language pathology & audiology 03 medical and health sciences Speech and Hearing 0302 clinical medicine McNemar's test Phonation Quality of life Statistical significance medicine Humans In patient Longitudinal Studies Prospective Studies 030223 otorhinolaryngology Aged business.industry Gold standard Recovery of Function Middle Aged Dysphonia LPN and LVN Adductor spasmodic dysphonia Treatment Outcome Otorhinolaryngology Quality of Life Female 0305 other medical science business |
| Zdroj: | Journal of Voice. 33:721-727 |
| ISSN: | 0892-1997 |
| DOI: | 10.1016/j.jvoice.2018.04.023 |
| Popis: | Summary Introduction Adductor spasmodic dysphonia (ADSD) is one of the most disabling voice disorders with no permanent cure. Patients with ADSD suffer from poor voice quality and repeated interruption of phonation that leads to limitations in daily communication. Botox (BT) injection, considered the gold standard treatment for ADSD, reduces the amount of voice breaks and improves voice quality for a limited period. In this study, patients with ADSD were followed after a single BT injection to track the changes in QOL and perceptual voice quality over a 6-month period. Method This is a prospective and longitudinal study. Fifteen patients with ADSD were evaluated preinjection and 1, 3, and 6 months postinjection. They completed the Voice Activity and Participation Profile-Persian Version (VAPPP) and read a passage at each recording period. Perceptual assessment was done by three expert speech-language pathologists with knowledge of ADSD using the grade, roughness, breathiness, asthenia, strain (GRBAS) scale. The data were analyzed using Friedman, Wilcoxon, and McNemar tests. The significance level was set at P Results The VAPPP total score and each of the domain scores reached their peak scores at 3 months postinjection. At 6 months postinjection, the VAPPP scores increased significantly in comparison with the 3-month scores and but were lower than preinjection scores. GRBAS results also indicated that patients' voices at 1 and 3 months postinjection were significantly less severe in terms of strain and roughness (P = 0.01; P Conclusion BT injection resulted in improvement of subjects' QOL. The improvement was greatest at 3 months postinjection but remained above the preinjection values at 6 months after injection. The voice quality also improved but was not judged as normal. |
| Databáze: | OpenAIRE |
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