Cytotoxic 4-Phenylcoumarins from the Leaves of Marila pluricostata
| Autor: | Dionisio Olmedo, José Luis López-Pérez, Arturo San Feliciano, Esther del Olmo, Mahabir P. Gupta, Yelkaira Vásquez, Pablo N. Solis |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Panama
Stereochemistry Pharmaceutical Science Fractionation Pharmacognosy Analytical Chemistry chemistry.chemical_compound Coumarins Clusiaceae Drug Discovery Tumor Cells Cultured Humans Phenols Cytotoxicity Nuclear Magnetic Resonance Biomolecular Marila Pharmacology chemistry.chemical_classification Plants Medicinal biology Organic Chemistry Biological activity biology.organism_classification Antineoplastic Agents Phytogenic In vitro Plant Leaves Complementary and alternative medicine chemistry Molecular Medicine Drug Screening Assays Antitumor Lactone |
| Zdroj: | Journal of Natural Products. 68:369-373 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Bioassay-guided fractionation of the CH(2)Cl(2) extract of the leaves of Marila pluricostata led to the isolation of 17 naturally occurring 4-phenylcoumarins, three of them, 5-hydroxy-8,8-dimethyl-4-phenyl-9,10-dihydro-8H-pyrano-[2,3-f]chromen-2-one (1), 5-hydroxy-8,8-dimethyl-4-phenyl-6-propionyl-9,10-dihydro-8H-pyrano-[2,3-f]chromen-2-one (2), and 5,7-dihydroxy-8-(3-methylbut-2-enyl)-4-phenylchromen-2-one (3), are new natural compounds; the remaining (4-17) are known mammea-type coumarins. Their structures were established by spectroscopic means. All compounds were tested in cytotoxicity assays against the MCF-7, H-460, and SF-268 human cancer cell lines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|