Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae
| Autor: | Christine A. Maggs, Matthew Carson, Vincent Laizé, Svenja Heesch, John Nelson, Brendan Gilmore, M. Leonor Cancela, Paulo J. Gavaia, Susan Clarke, Margaret Rae, Eugene Verzin |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cellular differentiation fracture risk Cell lcsh:Medicine Postmenopausal Osteoporosis fucoidan Macroalgae Osteogenesis Fracture Risk lcsh:Science Cells Cultured Zebrafish Bone growth Multidisciplinary Osteoblast Ceramium secundatum Cell Differentiation Men differentiation Vivo medicine.anatomical_structure Larva Differentiation women vivo macroalgae Stromal cell Cells men Red algae Biology Aquatic Science In Vitro Techniques Article Microbiology postmenopausal osteoporosis 03 medical and health sciences SDG 3 - Good Health and Well-being In vivo Fucoidan Plocamium lyngbyanum medicine Animals Humans Women SDG 14 - Life Below Water Bone Plocamium Cell Proliferation Marine algae Danio rerio Bone Development Plant Extracts lcsh:R Mesenchymal stem cell (MSC) Mesenchymal Stem Cells Cell Biology biology.organism_classification In vitro Marine extract 030104 developmental biology Rhodophyta cells Osteoporosis lcsh:Q |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018) Scientific Reports Carson, M, Nelson, J, Cancela, L, Laizé, V, Gavaia, P J, Rae, M, Heesch, S, Verzin, E, Maggs, C, Gilmore, B & Clarke, S 2018, ' Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae ', Scientific Reports, vol. 8, no. 7725, pp. 1-12 . https://doi.org/10.1038/s41598-018-26024-0 |
| ISSN: | 2045-2322 |
| Popis: | Through the current trend for bioprospecting, marine organisms - particularly algae - are becoming increasingly known for their osteogenic potential. Such organisms may provide novel treatment options for osteoporosis and other musculoskeletal conditions, helping to address their large healthcare burden and the limitations of current therapies. In this study, extracts from two red algae – Plocamium lyngbyanum and Ceramium secundatum – were tested in vitro and in vivo for their osteogenic potential. In vitro, the growth of human bone marrow stromal cells (hBMSCs) was significantly greater in the presence of the extracts, particularly with P. lyngbyanum treatment. Osteogenic differentiation was promoted more by C. secundatum (70 µg/ml), though P. lyngbyanum had greater in vitro mineralisation potential. Both species caused a marked and dose-dependent increase in the opercular bone area of zebrafish larvae. Our findings therefore indicate the presence of bioactive components in P. lyngbyanum and C. secundatum extracts, which can promote both in vitro and in vivo osteogenic activity. |
| Databáze: | OpenAIRE |
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