Subthalamic Deep Brain Stimulation Affects Plasma Corticosterone Concentration and Peripheral Immunity Changes in Rat Model of Parkinson’s Disease

Autor: Danuta Wrona, I. Majkutewicz, B. Grembecka, Piotr Badtke, K. Plucinska, Magdalena Listowska, G. Jerzemowska, Wojciech Glac
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Parkinson's disease
Deep brain stimulation
6-hydroxydopamine rat model of Parkinson’s disease
Neuroimmunomodulation
Lymphocyte
medicine.medical_treatment
Deep Brain Stimulation
Immunology
Population
Neuroscience (miscellaneous)
Deep brain stimulation of subthalamic nucleus
Apoptosis
behavioral disciplines and activities
Natural killer cell
03 medical and health sciences
0302 clinical medicine
Immune system
Parkinsonian Disorders
Dopamine
Subthalamic Nucleus
Internal medicine
Immunology and Allergy
Medicine
Animals
Lymphocytes
Rats
Wistar
education
Pharmacology
education.field_of_study
business.industry
medicine.disease
nervous system diseases
Rats
Subthalamic nucleus
030104 developmental biology
medicine.anatomical_structure
Endocrinology
surgical procedures
operative
nervous system
Cytokines
Original Article
business
Corticosterone
therapeutics
030217 neurology & neurosurgery
medicine.drug
Zdroj: Journal of Neuroimmune Pharmacology
ISSN: 1557-1904
1557-1890
Popis: Deep brain stimulation of the subthalamic nucleus (DBS-STN) is an effective treatment for advanced motor symptoms of Parkinson's disease (PD). Recently, a connection between the limbic part of the STN and side effects of DBS-STN has been increasingly recognized. Animal studies have shown that DBS-STN influences behavior and provokes neurochemical changes in regions of the limbic system. Some of these regions, which are activated during DBS-STN, are involved in neuroimmunomodulation. The therapeutic effects of DBS-STN in PD treatment are clear, but the influence of DBS-STN on peripheral immunity has not been reported so far. In this study, we examined the effects of unilateral DBS-STN applied in male Wistar rats with 6-hydroxydopamine PD model (DBS-6OHDA) and rats without nigral dopamine depletion (DBS) on corticosterone (CORT) plasma concentration, blood natural killer cell cytotoxicity (NKCC), leukocyte numbers, lymphocyte population and apoptosis numbers, plasma interferon gamma (IFN-γ), interleukin 6 (IL-6), and tumor necrosis factor (TNF-α) concentration. The same peripheral immune parameters we measured also in non-stimulated rats with PD model (6OHDA). We observed peripheral immunity changes related to PD model. The NKCC and percentage of T cytotoxic lymphocytes were enhanced, while the level of lymphocyte apoptosis was down regulated in 6OHDA and DBS-6OHDA groups. After DBS-STN (DBS-6OHDA and DBS groups), the plasma CORT and TNF-α were elevated, the number of NK cells and percentage of apoptosis were increased, while the number of B lymphocytes was decreased. We also found, changes in plasma IFN-γ and IL-6 levels in all the groups. These results suggest potential peripheral immunomodulative effects of DBS-STN in the rat model of PD. However, further studies are necessary to explain these findings and their clinical implication. Graphical Abstract Influence of deep brain stimulation of the subthalamic nucleus on peripheral immunity in rat model of Parkinson's disease.
Databáze: OpenAIRE
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