Presentation of pediatric Henoch–Schönlein purpura nephritis changes with age and renal histology depends on biopsy timing
| Autor: | Martin Bald, M Pohl, Martin Pohl, Henry Fehrenbach, Sabine U. König, Ulrike Walden, Charlotte Gimpel, Wiebke Aulbert, Gessa Schalk, Kristina Möller, Richard Nissel, Brigitte Mayer, Ortraud Beringer, Karsten Häffner, Peter F. Hoyer, Lutz T. Weber, Rolf Beetz, Imke Hennies, Thorsten Wiech, Matthias Hansen, Christian von Schnakenburg, Günter Klaus, Anja Büscher, M. Wallot, Jutta Gellermann, Elke Wühl, Gunhard Bertram, Katalin Dittrich, Simone Wygoda, Hagen Staude |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Henoch-Schonlein purpura IgA Vasculitis Biopsy 030232 urology & nephrology Medizin Renal function 030204 cardiovascular system & hematology Kidney Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Child Nephritis Proteinuria medicine.diagnostic_test business.industry Age Factors medicine.disease Pediatrics Perinatology and Child Health Female Histopathology Renal biopsy medicine.symptom business |
| Popis: | This study correlates the clinical presentation of Henoch–Schonlein purpura nephritis (HSPN) with findings on initial renal biopsy. Data from 202 pediatric patients enrolled in the HSPN registry of the German Society of Pediatric Nephrology reported by 26 centers between 2008 and 2014 were analyzed. All biopsy reports were re-evaluated for the presence of cellular crescents or chronic pathological lesions (fibrous crescents, glomerular sclerosis, tubular atrophy >5%, and interstitial fibrosis >5%). Patients with HSPN with cellular glomerular crescents were biopsied earlier after onset of nephritis (median 24 vs 36 days, p = 0.04) than those without, whereas patients with chronic lesions were biopsied later (57 vs 19 days, p < 0.001) and were older (10.3 vs 8.6 years, p = 0.01) than those without. Patients biopsied more than 30 days after the onset of HSPN had significantly more chronic lesions (52 vs 22%, p < 0.001), lower eGFR (88 vs 102 ml/min/1.73m2, p = 0.01), but lower proteinuria (2.3 vs 4.5 g/g, p |
| Databáze: | OpenAIRE |
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