Some Sulfur-Containing Metabolites of Tri-n-butyltin Chloride in Male Rats
| Autor: | Kazunari Kondo, Mitsuru Uchiyama, Mitsunori Murayama, Takashi Suzuki |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
chemistry.chemical_classification Metabolite General Chemistry Glutathione Urine Metabolism Models Biological Chloride Gas Chromatography-Mass Spectrometry Rats chemistry.chemical_compound Enzyme chemistry Microsome medicine Animals Organic chemistry Trialkyltin Compounds Mercapturic acid General Agricultural and Biological Sciences Sulfur Nuclear chemistry medicine.drug |
| Zdroj: | Journal of Agricultural and Food Chemistry. 47:4791-4798 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf9903408 |
| Popis: | In an attempt to elucidate metabolic destination of TBTO, sulfur-containing metabolites were investigated in the urine. Tri-n-butyltin chloride (TBTC), tri-n-butyltin oxide (TBTO), and their in vitro metabolites in rat liver microsomal enzyme systems, di-n-butyl(3-hydroxybutyl)tin chloride (T3OH), di-n-butyl(3-oxobutyl)tin chloride (T3CO), dibutyltin dichloride (DBTC), and monobutyltin trichloride (MBTC), were intraperitoneally administered to rats. In particular, administration of T3OH and T3CO gave higher amounts of mercapturic acid derivatives, such as N-acetyl-S-(3-oxobutyl)-L-cysteine (3CO-MA) and N-acetyl-S-(3-hydroxybutyl)-L-cysteine (3OH-MA), than TBTC or TBTO. On the other hand, DBTC and MBTC did not yield measurable amounts of 3CO-MA and/or 3OH-MA. The appearance of organotin metabolites in urine indicates that T3OH, T3CO, and hypothesized secondary metabolites, such as n-butyl(3-hydroxybutyl)(3-oxobutyl)tin chloride, n-butyl(3-hydroxybutyl)(4-hydroxybutyl)tin chloride, etc., are subject to the action of glutathione S-transferase to give mercapturic acid derivatives. These sulfur-containing metabolites (3CO-MA and 3OH-MA) were also found in control rat urine. |
| Databáze: | OpenAIRE |
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