The Ala Allele at Val762Ala Polymorphism in Poly(ADP-ribose) Polymerase-1 (PARP-1) Gene is Associated with a Decreased Risk of Asthma in a Turkish Population
| Autor: | Bülent Tutluoğlu, Gulcin Tezcan, Gonul Kanigur-Sultuybek, Cigdem Bayram Gurel, İlhan Onaran |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Poly Adenosine Diphosphate Ribose Turkish population Turkey Poly ADP ribose polymerase Polymerase Chain Reaction Risk Assessment Severity of Illness Index law.invention Age Distribution Reference Values law Polymorphism (computer science) Genotype Confidence Intervals Odds Ratio Genetic predisposition Humans Immunology and Allergy Medicine Genetic Predisposition to Disease Sex Distribution Allele Alleles Polymerase chain reaction Probability Analysis of Variance Polymorphism Genetic business.industry Incidence Wild type Prognosis Molecular biology Asthma Gene Expression Regulation Case-Control Studies Pediatrics Perinatology and Child Health Female Poly(ADP-ribose) Polymerases business |
| Zdroj: | Journal of Asthma. 46:371-374 |
| ISSN: | 1532-4303 0277-0903 |
| DOI: | 10.1080/02770900902777791 |
| Popis: | It has been suggested that inhibition of poly (ADP-ribose) polymerase-1 (PARP-1), either pharmacologically or by a gene knockout provides significant protection against systemic or tissue inflammation in animal models. The aim of this study was to analyze the association of the PARP-1 Val762Ala polymorphism, which has beenreported to be associated with decreased enzymatic activity, in Turkish patients with adult asthma.A total of 112 subjects with stable asthma and 180 normal controls from the same geographic region were studied and polymerase chain reaction-based restriction analysis was used to identify Val762Ala polymorphism of the PARP-1.In univariate analysis, PARP-1 762 AA genotype conferred a 3.4 fold reduction in risk (OR = 0.297, 95% CI = 0.105-0.813; P = 0.014), while heterozygous VA genotype conferred an even greater level of protection (OR = 0.06; 95%CI, 0.026-0.14; P10(-6)). In addition, wild type PARP-1 762 V allele had 5 times the risk of developing asthma than those without the allele (OR 0.199, CI 0.118-0.334, P = 10(-6)).These findings suggest that PARP-1 V762A variants may be one of the factors participating in protection or susceptibility to asthma in our population. |
| Databáze: | OpenAIRE |
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