Sedative and physiological effects of low-dose intramuscular alfaxalone in rabbits
| Autor: | Mohammed A. Umar, Kazuto Yamashita, Norihiko Oyama, Hisashi Sakata, Yushun Ishikawa, Yuuri Tachibana, Takaharu Itami, Tadashi Sano |
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| Rok vydání: | 2019 |
| Předmět: |
Respiratory rate
040301 veterinary sciences medicine.drug_class Sedation rabbit Blood Pressure Injections Intramuscular Pregnanediones 0403 veterinary science Reflex Righting 03 medical and health sciences Respiratory Rate Heart Rate Interquartile range medicine Animals Hypnotics and Sedatives 030304 developmental biology 0303 health sciences Dose-Response Relationship Drug Full Paper alfaxalone General Veterinary business.industry Alfaxalone Low dose Apnea 04 agricultural and veterinary sciences Oxygen Blood pressure sedation intramuscular administration Sedative Anesthesia Female Surgery Rabbits medicine.symptom business medicine.drug |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.18-0618 |
| Popis: | To evaluate sedative and physiological effects of low dose intramuscular (IM) alfaxalone, six healthy rabbits were administered single IM doses of alfaxalone at 1mg/kg (IM1), 2.5 mg/kg (IM2.5), or 5 mg/kg (IM5) with a minimum of 7-day washout period. Sedative effects were subjectively evaluated using a composite measure scoring system (maximum sedation score of 16) and pulse rate, respiratory rate, non-invasive blood pressure, and percutaneous oxygen-hemoglobin saturation were measured before and after IM alfaxalone. Loss of righting reflex (LRR) was achieved in all rabbits after IM2.5 and IM5 treatments but in only three rabbits after IM1 treatment. Median (interquartile range) times to LRR were 16 min (15–17), 6 min (6–6), and 4 min (4–4), and median durations of LRR were 0.5 min (0–7), 22.5 min (19–27), and 53 min (48–58) after IM1, IM2.5, and IM5 treatments, respectively. The duration of LRR after IM5 treatment was significantly longer than those after IM1and IM2.5 treatments (P |
| Databáze: | OpenAIRE |
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