Risk factors for unfavorable clinical outcomes in patients with brain abscess in South Korea

Autor: Yae Jee Baek, Joon Sup Yeom, Jun Yong Choi, Su Jin Jeong, Jin Young Ahn, Moo Hyun Kim, Jong Hoon Hyun, Yu Jin Sohn, Yun Suk Cho, Jung Ho Kim, Nam Su Ku, Young Goo Song
Rok vydání: 2021
Předmět:
Male
Multivariate analysis
Epidemiology
Organ Dysfunction Scores
Comorbidity
Severity of Illness Index
Mathematical and Statistical Techniques
Antibiotics
Risk Factors
Medicine and Health Sciences
Neurological findings
Brain Damage
Multidisciplinary
Antimicrobials
Headaches
Mortality rate
Medical record
Statistics
Age Factors
Drugs
Middle Aged
Treatment Outcome
Neurology
Physical Sciences
Medicine
Female
medicine.symptom
Research Article
Adult
medicine.medical_specialty
Death Rates
Science
Brain Abscess
Surgical and Invasive Medical Procedures
Brain damage
Research and Analysis Methods
Gram-Positive Bacteria
Microbiology
Signs and Symptoms
Population Metrics
Microbial Control
Internal medicine
Gram-Negative Bacteria
Republic of Korea
medicine
Humans
In patient
Statistical Methods
Brain abscess
Aged
Retrospective Studies
Pharmacology
Population Biology
business.industry
Biology and Life Sciences
Retrospective cohort study
medicine.disease
Abscesses
Medical Risk Factors
Multivariate Analysis
Clinical Medicine
business
Mathematics
Zdroj: PLoS ONE, Vol 16, Iss 9, p e0257541 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Background Brain abscess can be life-threatening and manifest various neurological findings, although the mortality rate has decreased recently. We investigated the risk factors for unfavorable outcomes of patients with brain abscess. Methods A retrospective cohort study examined patients with brain abscess seen from May 2005 to December 2018 in a tertiary care hospital in Seoul, South Korea. We reviewed the medical records for clinical findings, therapeutic modalities, and prognostic factors of brain abscess. Unfavorable clinical outcomes were defined as death, moderate to severe disability with neurological deficits, or vegetative state at 1 year or at the time of discharge from outpatient follow-up. Results The study enrolled 135 patients: 65.2% were males; the mean age was 56 years. 35.6% had unfavorable outcomes. In multivariate analysis, higher Sequential Organ Failure Assessment (SOFA) (p < 0.001), pre-existing hemiplegia (p = 0.049), and higher Charlson comorbidity index (CCI) (p = 0.028) were independently associated with unfavorable outcomes. Conclusions Higher SOFA, pre-existing hemiplegia and higher Charlson comorbidity index were significant risk factors for unfavorable clinical outcomes in patients with brain abscess.
Databáze: OpenAIRE
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