Sex disparities in the current era of pediatric heart transplantation in the United States
| Autor: | Elizabeth V. Saarel, Shahnawaz Amdani, Wei Liu, Sarah Worley, Hannah Bostdorff, Colleen Nasman, Eileen Hsich, Gerard J. Boyle, Salima A. Bhimani |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pediatrics medicine.medical_specialty Adolescent Heart disease medicine.medical_treatment Article medicine Humans Healthcare Disparities Sex Distribution Child Retrospective Studies Heart transplantation Transplantation business.industry Infant Implantable cardioverter-defibrillator medicine.disease United States Child Preschool Propensity score matching Cohort Heart Transplantation Female Surgery Liver dysfunction Pediatric heart transplantation Cardiology and Cardiovascular Medicine business |
| Zdroj: | J Heart Lung Transplant |
| ISSN: | 1053-2498 |
| DOI: | 10.1016/j.healun.2021.10.021 |
| Popis: | BACKGROUND: While sex-related differences in transplant outcomes have been well characterized amongst adults, there are no sex-specific pediatric heart transplant studies over the last decade and none evaluating waitlist outcomes. In a contemporary cohort of children undergoing heart transplantation in the United States, this analysis was performed to determine if there were sex disparities in waitlist and/or post-transplant outcomes. METHODS: Retrospective review of Scientific Registry of Transplant Recipients database from December 16, 2011 to February 28, 2019 to compare male and female children after listing and after transplant. Demographic, clinical characteristics and outcomes were compared unadjusted and after 1:1 propensity matching for selected covariates. RESULTS: Of 4089 patients, 2299 (56%) were males. At listing, males were more likely to be older, have congenital heart disease (58% vs 48%), renal dysfunction (49% vs 44%) and implantable cardioverter defibrillator (9% vs 7%). At transplant, males were more likely to have renal (42 % vs 35%) and liver dysfunction (13% vs 10%), PRA >10% (29% vs 22%) and ischemic time >3.5 hours (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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