Infant growth and aorta total lipid fatty acids
| Autor: | A. G. Howatson, E. C. Jamieson, J Farquharson, R W Logan, F. Cockburn, M B McFadyen, W. J. A. Patrick |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Aorta Thoracic Infant Premature Diseases Statistics Nonparametric chemistry.chemical_compound 8 11 14-Eicosatrienoic Acid Internal medicine medicine.artery medicine Humans Aorta Abdominal Growth Disorders chemistry.chemical_classification Fetus Aorta Arachidonic Acid business.industry Fatty Acids Abdominal aorta Infant Newborn Infant Fatty acid Original Articles Sudden infant death syndrome medicine.disease Bottle Feeding Failure to Thrive Oleic acid Endocrinology chemistry Infant Small for Gestational Age Pediatrics Perinatology and Child Health Small for gestational age lipids (amino acids peptides and proteins) Endothelium Vascular business Infant Premature Sudden Infant Death Oleic Acid Polyunsaturated fatty acid |
| Zdroj: | Archives of Disease in Childhood. 79:28-32 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.79.1.28 |
| Popis: | Abnormal fetal and infant growth have increasingly been correlated with adult onset cardiovascular disease. To date, there is little known about the lipid fatty acid profiles in infant cardiovascular tissue. Therefore, we analysed total lipid fatty acids from thoracic and abdominal aorta intima and media from 24 normally grown sudden infant death syndrome cases. Aorta from small for gestational age (n = 2), failure to thrive from birth (n = 3), and premature (n = 1) infants were also examined. Dihomo-gamma-linolenic acid (C20:3n-6) and oleic acid (C18:1n-9) concentrations were significantly lower in the thoracic than in the abdominal aorta. Similar dietary related differences were found in the subgroup (n = 15) of infants fed on formula milks. Both abdominal and thoracic intimal arachidonic (C20:4n-6) to dihomo-gamma-linolenic acid ratios were greater in the infants with retarded growth after birth than in their normally grown counterparts. Growth restriction in infancy might disrupt the normal accretion of vascular endothelial polyunsaturated fatty acids. |
| Databáze: | OpenAIRE |
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