Local injection to sciatic nerve of dexmedetomidine reduces pain behaviors, SGCs activation, NGF expression and sympathetic sprouting in CCI rats
Autor: | Jie Wang, Bo Zhou, Ying-ying Yao, Ming-ming Zhang, Hui Chen, Jing-ru Wu, Deng-xin Zhang, Kai Jiang |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Agonist Male medicine.medical_specialty Spinal Cord Dorsal Horn medicine.drug_class Rats Sprague-Dawley 03 medical and health sciences Random Allocation 0302 clinical medicine Internal medicine Nerve Growth Factor medicine Adrenergic alpha-2 Receptor Agonists Animals Dexmedetomidine Receptor Neurons Microglia business.industry General Neuroscience Analgesics Non-Narcotic Sciatic Nerve Disease Models Animal 030104 developmental biology medicine.anatomical_structure Nerve growth factor Endocrinology Nociception Anesthesia Neuropathic pain Neuralgia Sciatic nerve Chronic Pain business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Brain research bulletin. 132 |
ISSN: | 1873-2747 |
Popis: | Neuropathic pain has become an intractable health threat, with its profound effect on quality of life. Dorsal root ganglia (DRG) is evidenced to play a crucial role in neuropathic pain. The peripheral nociceptive afferents seem to be essential not only to initiate the process of neuropathic pain, but also to maintain and modulate it. Dexmedetomidine (DEX), a highly selective agonist of α2-adrenergic receptor (α2-AR), has provided significant analgesia in neuropathic pain. In the present study, we found that local injection to sciatic nerve of DEX alleviated heat hypersensitivity induced by chronic constriction injury (CCI). Western blotting revealed that DEX inhibited the over-expression of nerve growth factor (NGF) significantly. Immunohistofluorescence results showed that DEX inhibited glia cells activation and sympathetic sprouting simultaneously in DRG. Our study suggests that DEX attenuates neuropathic pain in CCI rats by down-regulation of satellite glial cells (SGCs) activation, NGF expression and sympathetic sprouting. |
Databáze: | OpenAIRE |
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