A Comparison of Respiratory Syncytial Viral Prophylaxis in Multiple Births versus Singletons in the Canadian Registry of Palivizumab
| Autor: | Abby Li, Caress Investigators, Doyoung Kim, Krista L. Lanctôt, Ian Mitchell, Bosco Paes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Palivizumab Canada Pediatrics medicine.medical_specialty Birth weight Gestational Age Respiratory Syncytial Virus Infections Lower risk Antiviral Agents 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors medicine Humans Prospective Studies Registries Proportional Hazards Models 030219 obstetrics & reproductive medicine business.industry Proportional hazards model Hazard ratio Infant Newborn Pregnancy Outcome Infant Obstetrics and Gynecology Gestational age Confidence interval Pediatrics Perinatology and Child Health Female Pre-Exposure Prophylaxis Multiple birth Pregnancy Multiple business medicine.drug |
| Zdroj: | American Journal of Perinatology. 38:e129-e136 |
| ISSN: | 1098-8785 0735-1631 |
| DOI: | 10.1055/s-0040-1708804 |
| Popis: | Objective The aim of this study is to compare respiratory illness-related hospitalization (RIH) and respiratory syncytial virus (RSV)-related hospitalization (RSVH) in multiple births versus singletons, who received palivizumab during the RSV season and participated in the Canadian registry of palivizumab (CARESS). Study Design Prospective, observational study of infants aged Results A total of 25,003 infants were enrolled of whom 6,949 (27.8%) were of multiple birth, and 18,054 (72.2%) were singletons. A significantly larger proportion of the multiple births were premature (80.2%) compared with the singleton group (56.8%). Multiples had a lower gestational age (mean ± standard deviation): 31.2 ± 3.2 versus 33.2 ± 5.5 weeks and birth weight (mean: 1,590 ± 606.8 vs. 2,069.4 ± 1068.5 g; both p Conclusion Multiple birth infants, who are known to be at greater risk for severe RSVH compared with singletons, are well protected by palivizumab, provided adherence to the monthly injection scheme is guaranteed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|