Astragalus Polysaccharide Extends Lifespan via Mitigating Endoplasmic Reticulum Stress in the Silkworm, Bombyx mori
Autor: | Xiaoling Tong, Hai Hu, Jianfei Zhang, Jiangbo Song, Zhiquan Li, Fangyin Dai, Min Chen |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Stimulation Biology Orginal Article Pathology and Forensic Medicine Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Downregulation and upregulation Bombyx mori Glucose homeostasis astragalus polysaccharide silkworm Caenorhabditis elegans experimental animal Endoplasmic reticulum fungi Cell Biology Glutathione biology.organism_classification Cell biology drug efficacy 030104 developmental biology chemistry biology.protein endoplasmic reticulum stress Neurology (clinical) Geriatrics and Gerontology 030217 neurology & neurosurgery lifespan |
Zdroj: | Aging and Disease |
ISSN: | 2152-5250 |
Popis: | The traditional Chinese medicine Astragalus polysaccharide (APS) has been widely used to improve glucose homeostasis and immunoregulator properties. In recent years, it has also been shown to extend the lifespan of Caenorhabditis elegans; however, the underlying molecular mechanisms are not fully understood. Here, our study shows that APS could significantly extend adult stage, mean, and maximum lifespan of the silkworm, Bombyx mori and increase body weight without affecting food intake and fecundity. Meanwhile, the activities of glutathione S-transferase and superoxide dismutase are significantly enhanced, and the reaction oxygen species content is reduced concomitantly. Moreover, the activity of lysozyme is increased dramatically. In addition, APS rescues the shortened lifespan by Bacillus thuringiensis infection in silkworm. Furthermore, the transcription of the crucial genes involved in endoplasmic reticulum stress is upregulated upon the endoplasmic reticulum stress stimulation. APS also significantly ameliorates endoplasmic reticulum stress in silkworm cell line and in vivo. Together, the results of this study indicate that APS can prolong the silkworm lifespan by mitigating endoplasmic reticulum stress. This study improves our understanding of the molecular mechanism of APS-induced lifespan extension and highlights the importance of the silkworm as an experimental animal for evaluating the effects and revealing the mechanisms in lifespan extension of traditional Chinese medicine. |
Databáze: | OpenAIRE |
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