Use of antihistamines before or during pregnancy and risk of early-onset pre-eclampsia in allergic women: a population-based cohort study

Autor:	Anne K Sande, Erik Andreas Torkildsen, Ragnar Kvie Sande, Ingvild Dalen, Kim Christian Danielsson, Nils-Halvdan Morken
Rok vydání:	2022
Předmět:	Cohort Studies Male Pre-Eclampsia Pregnancy Risk Factors Histamine Antagonists Hypersensitivity Humans Female General Medicine
Zdroj:	e061837 BMJ Open
ISSN:	2044-6055
DOI:	10.1136/bmjopen-2022-061837
Popis:	ObjectiveWe have previously found that allergy is a risk factor for early-onset pre-eclampsia. The aim of this study was to assess the association between pregestational maternal use of antihistamines and early-onset pre-eclampsia.DesignA population-based cohort study.Setting and participantsAll women giving birth in Norway 2004–2016, including 692 487 pregnancies. Data from the Medical Birth Registry of Norway were linked with data from the Norwegian Prescription Database. Prescriptions of antihistamines were divided into three groups: before pregnancy (InterventionsUse of antihistamines in relation to pregnancy in allergic women.Main outcome measuresDevelopment of early-onset pre-eclampsia.Results2997 (0.43%) and 5769 (0.83%) women had pre-eclampsia ConclusionsAntihistamine use before or during placentation was associated with reduced risk of developing early-onset pre-eclampsia in allergic women compared with women using antihistamines after placentation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd17027f795464ac7cea4206296583a https://doi.org/10.1136/bmjopen-2022-061837 Zobrazit plný text záznamu