Calculation of therapeutic activity of radioiodine in Graves' disease by means of Marinelli's formula, using technetium (
| Autor: | Monika Sykała, Anna Amelian-Fiłonowicz, Saeid Abdelrazek, Małgorzata Mojsak, Dorota Jurgilewicz, Janusz Myśliwiec, Piotr Szumowski |
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| Rok vydání: | 2016 |
| Předmět: |
Male
endocrine system endocrine system diseases Endocrinology Diabetes and Metabolism Graves' disease chemistry.chemical_element 030209 endocrinology & metabolism Trab Scintigraphy Technetium 030218 nuclear medicine & medical imaging Thyroid technetium uptake Iodine Radioisotopes Thyroid iodine uptake 03 medical and health sciences 0302 clinical medicine Endocrinology medicine Humans Euthyroid Radionuclide Imaging Marinelli’s formula medicine.diagnostic_test business.industry Thyroid Organotechnetium Compounds medicine.disease Graves Disease medicine.anatomical_structure chemistry Original Article Female Graves’ disease Nuclear medicine business Technetium-99m Algorithms |
| Zdroj: | Endocrine |
| ISSN: | 1559-0100 |
| Popis: | The therapeutic activity of 131I administered to patients with Graves’ disease can be calculated by means of Marinelli’s formula. The thyroidal iodine uptake (131IUmax) needed for the calculation is usually determined with the use of 131I. The purpose of the paper was to estimate 131IUmax on the basis of technetium uptake in the thyroid at 20 min (99mTcU20min). Eighty patients suffering from Graves’ disease were qualified for radioiodine therapy with measurement of fT4, fT3, thyroid-stimulating hormone and its receptor (TRAb). Prior to the treatment, all the patients were euthyroid. 131IUmax for each patient was determined according to the levels of 131I after 24 h (131IU24h), while effective half-life (T eff) according to the measurements of 131IU24h and 131I uptake after 48 h (131IU48h). Additionally, on the day before measuring 131IU24h, 99mTcU20min was calculated for each patient. It was demonstrated that there existed a correlation, with statistical significance at p 10 IU/ml. It is possible to predict thyroid iodine uptake 131IU24h in Graves’ disease on the basis of measuring the uptake of 99mTcU20min. This shortens the time necessary for diagnosis and enables the calculation of 131I activity using Marinelli’s formula. |
| Databáze: | OpenAIRE |
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