Prenatal exposure to antiepileptic drugs and early processing of emotionally relevant sounds

Autor: Valtteri Wikström, Mari Videman, Sampsa Vanhatalo, Susanna Stjerna, Eija Gaily, Reina Roivainen, Minna Huotilainen, Taina Nybo
Přispěvatelé: HUS Children and Adolescents, Children's Hospital, HUS Neurocenter, Kliinisen neurofysiologian yksikkö, Department of Psychology and Logopedics, Cognitive Brain Research Unit, Neurologian yksikkö, Department of Neurosciences, HUS Medical Imaging Center, University of Helsinki, Department of Education, Behavioural Sciences, CICERO Learning, Lastenneurologian yksikkö, AGORA for the study of social justice and equality in education -research centre, Brain, Music and Learning, Mind and Matter
Rok vydání: 2019
Předmět:
Male
Developmental Disabilities
Emotions
LANGUAGE
Mismatch negativity
CHILDREN
Audiology
3124 Neurology and psychiatry
Cohort Studies
Behavioral Neuroscience
Epilepsy
0302 clinical medicine
Pregnancy
EVOKED-POTENTIALS
Spectrum disorder
Attention
030212 general & internal medicine
Neurologic Examination
Psycholinguistics
medicine.diagnostic_test
VALPROATE EXPOSURE
Neuropsychology
Evoked potentials
Verbal reasoning
3. Good health
Neurology
Prenatal Exposure Delayed Effects
Auditory Perception
Speech Perception
Anticonvulsants
Female
TERM INFANTS
COGNITIVE OUTCOMES
medicine.medical_specialty
MISMATCH NEGATIVITY MMN
515 Psychology
EVENT-RELATED POTENTIALS
Neurological examination
Fetal
03 medical and health sciences
Event-related potential
medicine
Humans
Intrauterine
SPECTRUM DISORDER
business.industry
Auditory Perceptual Disorders
Infant
Newborn
Infant
Newborn
medicine.disease
DISCRIMINATION
Case-Control Studies
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Epilepsybehavior : EB. 100
ISSN: 1525-5069
Popis: Introduction: Prenatal exposure to antiepileptic drugs (AEDs) is associated with developmental compromises in verbal intelligence and social skills in childhood. Our aim was to evaluate whether a multifeature Mismatch Negativity (MMN) paradigm assessing semantic and emotional components of linguistic and emotional processing would be useful to detect possible alterations in early auditory processing of newborns with prenatal AED exposure. Material and methods: Data on AED exposure. pregnancy outcome, neuropsychological evaluation of the mothers, information on maternal epilepsy type, and a structured neurological examination of the newborn were collected prospectively. Blinded to AED exposure, we compared a cohort of 36 AED-exposed with 46 control newborns at the age of two weeks by measuring MMN with a multifeature paradigm with six linguistically relevant deviant sounds and three emotionally uttered sounds. Results: Frontal responses for the emotionally uttered stimulus Happy differed significantly in the exposed newborns compared with the control newborns. In addition, responses to sounds with or without emotional component differed in newborns exposed to multiple AEDs compared with control newborns or to newborns exposed to only one AED. Conclusions: These preliminary findings suggest that prenatal AED exposure may alter early processing of emotionally and linguistically relevant sound information. (C) 2019 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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