Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma
| Autor: | Lei Liu, Lin Bao, Wen Jun Hu, Chang Fei Yuan, Yan Qu, Yao Ying Gao, Ze Yuan Ru, Guanghua Xu, Hong Mei Yang, Xiang Li, Xuanyu Chen, Hai Bin Xiao, Jun Wei Tong, Zheng Shuai Song, Ke Chen, Xiaoping Zhang, Zhi Yong Xiong, Ke Shan Wang, Hai Long Ruan, Wen Xiao, Qi Cao |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Indoles Caveolin 1 Biology urologic and male genital diseases Metastasis Young Adult 03 medical and health sciences 0302 clinical medicine Cell Movement Renal cell carcinoma Sunitinib medicine Humans Neoplasm Invasiveness Pyrroles Carcinoma Renal Cell Aged Cell Proliferation Aged 80 and over Gene knockdown Cell migration Cell Biology Middle Aged Prognosis medicine.disease Kidney Neoplasms Gene Expression Regulation Neoplastic Clear cell renal cell carcinoma 030104 developmental biology Drug Resistance Neoplasm Gene Knockdown Techniques 030220 oncology & carcinogenesis Immunology Cancer research Female Kidney cancer medicine.drug |
| Zdroj: | Experimental Cell Research. 358:269-278 |
| ISSN: | 0014-4827 |
| Popis: | Caveolin-1 (CAV1) has been identified to be up-regulated in many cancers, including clear cell renal cell carcinoma (ccRCC). However, its potential function is still unclear in ccRCC. In this study, we demonstrated that CAV1 was frequently overexpressed in renal cell carcinoma tissues and cells, and was significantly associated with various clinicopathological parameters. In addition, high CAV1 expression was associated with poor disease-free survival (DFS) rate and could serve as a useful diagnostic indicator in ccRCC patients with different clinicopathological stages. Functional experiments demonstrated that CAV1 knockdown inhibited cell migration and invasion, whereas overexpression of CAV1 promoted cell migration and invasion in ccRCC. Moreover, CAV1 expression was up-regulated in sunitinib-resistant renal cancer cell lines, and its overexpression promoted sunitinib resistance. In general, our results confirm that CAV1 plays an important role in the metastasis of kidney cancer and induces sunitinib resistance, so CAV1 function suppression may become a promising clinical treatment strategy during renal cell carcinoma metastasis and sunitinib resistance. |
| Databáze: | OpenAIRE |
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