The role of soluble urokinase plasminogen activator receptor (SuPAR) as an indicator of the severity of acute pancreatitis
| Autor: | Kadir Küçükceran, Abdullah Sadik Girisgin, Tamer Colak, Mehmet Gül, Sedat Koçak, Alpay Tuncar, Ibrahim Kilinc, Adnan Karaibrahimoğlu, Basar Cander, Zerrin Defne Dundar, Mehmet Ergin |
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| Přispěvatelé: | Kadir Küçükceran: 0000-0001-9758-0803, Mehmet Ergin: 0000-0002-9420-6514, İbrahim Kılınç: 0000-0002-7729-7557, Adnan Karaibrahimoğlu: 0000-0002-8277-0281, Tamer Çolak: 0000-0003-3844-4785, Alpay Tuncar: 0000-0002-3889-819X, Zerrin Defne Dündar: 0000-0001-6431-5800, Sedat Koçak: 0000-0001-8265-9615, Abdullah Sadık Girişgin: 0000-0003-2669-0532, Mehmet Gül: 0000-0003-3815-1667, Başar Cander: 0000-0003-1035-1907, Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Anabilim Dalı, Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Temel Tıp Bilimleri, Biyoistatistik ve Tıbbi Bilişim Anabilim Dalı, Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Biyokimya Anabilim Dalı |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Supar
Abdominal pain medicine.medical_specialty business.industry Urokinase Plasminogen Activator Acute pancreatitis biomarker abdominal pain suPAR Biomarker General Medicine Disease medicine.disease Gastroenterology Acute pancreatitis SuPAR Health Care Sciences and Services Internal medicine medicine Pancreatitis Prospective research medicine.symptom Sağlık Bilimleri ve Hizmetleri business Receptor |
| Zdroj: | Volume: 48, Issue: 6 1175-1181 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | WOS:000452890300015 PubMed ID: 30541244 Background/aim: Soluble urokinase plasminogen activator receptor (suPAR) has been reported to have a positive correlation with theactivation degree of the immune system. This study’s aim is to investigate the efficiency of SuPAR serum levels in acute pancreatitis (AP)patients in determining the severity of disease.Materials and methods: This prospective research involves patients who arrived at the emergency service, were over 18 years old, hadnontraumatic abdominal pain and diagnosis of AP, and agreed to join the study. Demographic characteristics, contact information,laboratory and imaging test parameters, Ranson’s criteria, the Balthazar Severity Index, the Rapid Acute Physiologic Score (RAPS), andthe modified Glasgow (Imrie) score of all patients were recorded. Two study groups were created as score of 3 (mild, Group I) and 3(severe, Group II) for pancreatitis according to Ranson’s criteria.Results: During the study period, 59 sequential patients with AP were included in the study. It was seen that 79.7% of the study group(n 47) were in Group I. Etiologically 67.8% (n 40) cases were biliary and 32.3% (n 19) were nonbiliary diseases. According to theresults, suPAR level was effective in distinguishing the severity of AP (AUC 0.902, P 0.001 (95% CI: 0.821–0.984)). With regardto determining severe disease, suPAR had an optimum cutoff value of 6.815 ng/mL, sensitivity of 91.66%, specificity of 82.97%, andnegative predictive value of 97.5%.Conclusion: Our study was performed the determine the efficiency of suPAR level in predicting severe disease in AP patients. We foundit significant in indicating the severity of disease according to the study results. |
| Databáze: | OpenAIRE |
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