Markers of human T lymphotropic virus type I in patients with cancer of uterine cervix in Amazon, Brazil

Autor:	R TamezGuerra, T Fukushima, Luis Isamu Barros Kanzaki, E. Neitzert, Jorge Casseb, João Emílio Macedo, K Maruyama, Laura M. Trejo-Avila
Rok vydání:	1997
Předmět:	Cervical cancer Cancer Research biology Oncogene viruses Cancer Human T-lymphotropic virus biology.organism_classification medicine.disease Virology Virus Blot Oncology Immunology medicine biology.protein Viral disease Antibody
Zdroj:	Scopus-Elsevier
ISSN:	1791-2423 1019-6439
Popis:	Human T lymphotropic virus type I(HTLV-I) has been implicated in various human diseases. Serum samples of 390 Brazilian Amazonians with cancer of various types were tested for HTLV-I antibodies by Gelatin particle agglutination test, Enzyme linked immunosorbent assay and Western blotting. Of 134 sera from patients with cancer of uterine cervix, 4 were positive by all the methods. Three of these were from non-transfused patients. DNA was extracted from 2 of 4 seropositive sera that gave strong reactions and were analyzed by PCR-SSCP for HTLV-I sequences. One was positive for all HTLV-I genes tested while the other one was positive for LTR and tax and negative for gag. In view of a possible pathway of the virus by sexual contact, the involvement of HTLV-I in cervical cancer warrants further studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcc6008bbe1de2b24eef878d134913f https://doi.org/10.3892/ijo.10.5.1021 Zobrazit plný text záznamu