Cytokine Secretion and Markers of Inflammation in Relation to Acidosis among Chronic Hemodialysis Patients
| Autor: | Hanna Bessler, Hertzel Salman, Boris Zingerman, Michael Bergman, Yaacov Ori, Uzi Gafter, Rachel S. Levy-Drummer |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Inflammation Peripheral blood mononuclear cell Renal Dialysis Internal medicine medicine Humans Cells Cultured Dialysis Aged Acidosis Aged 80 and over Interleukin-6 business.industry Age Factors Metabolic acidosis Hematology General Medicine Middle Aged Prognosis medicine.disease Interleukin-10 Bicarbonates Interleukin 10 Endocrinology Parathyroid Hormone Nephrology Leukocytes Mononuclear Kidney Failure Chronic Female Cytokine secretion Hemodialysis medicine.symptom business Biomarkers |
| Zdroj: | Blood Purification. 35:181-186 |
| ISSN: | 1421-9735 0253-5068 |
| DOI: | 10.1159/000346689 |
| Popis: | Background: Various cytokines are increased in hemodialysis (HD) patients, and are considered prognostic markers. Metabolic acidosis is common among chronic HD patients and is associated with survival. The relationship between acidosis and cytokines in HD patients has not been fully explored. The study aim was to measure pro- and anti-inflammatory cytokines in HD patients, with relation to bicarbonate levels. Methods: Forty-seven stable HD patients were included (male/female 28/19, mean age 70.4 ± 14.5 years). Blood tests were taken before a midweek dialysis session. Cytokine secretion from peripheral blood mononuclear cells was measured. Results: Acidosis versus no acidosis (serum HCO3- 21.5 ± 0.2 vs. 24.9 ± 0.3 mEq/l, p < 0.001) was associated with decreased secretion of the anti-inflammatory interleukin-10 (IL-10, 1.16 ± 0.11 vs. 1.71 ± 0.20 ng/ml, p = 0.023). Patients with acidosis had higher parathyroid hormone (PTH), calcium-phosphate product, protein intake and transferrin. Higher IL-10 was associated with increased IL-6 secretion, higher bicarbonate, younger age and lower PTH. Conclusions: In stable chronic HD patients, a possible direct relation exists between metabolic acidosis and IL-10. |
| Databáze: | OpenAIRE |
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