The role played by the interaction between genetic factors and attachment in the stress response in infancy

Autor:	Marianna Rusconi, Pasco Fearon, Maria Elisabetta Raggi, Roberto Giorda, Alessandra Frigerio, Elisa Ceppi
Rok vydání:	2009
Předmět:	Adult Male medicine.medical_specialty Hypothalamo-Hypophyseal System Hydrocortisone GABRA6 Pituitary-Adrenal System Genetic determinism Salivary Glands Developmental psychology Internal medicine Developmental and Educational Psychology medicine Humans Family Amylase Allele Gene–environment interaction Object Attachment Alleles Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic biology Receptors Dopamine D4 Infant Receptors GABA-A Mother-Child Relations Psychiatry and Mental health Endocrinology Child Preschool Pediatrics Perinatology and Child Health biology.protein Strange situation Female alpha-Amylases Psychology Stress Psychological medicine.drug
Zdroj:	Journal of child psychology and psychiatry, and allied disciplines. 50(12)
ISSN:	1469-7610
Popis:	Background: The importance of understanding which environmental and biological factors are involved in determining individual differences in physiological response to stress is widely recognized, given the impact that stress has on physical and mental health. Methods: The child-mother attachment relationship and some genetic polymorphisms (5-HTTLPR, COMT and GABRA6) were tested as predictors of salivary cortisol and alpha amylase concentrations, two biomarkers of hypothalamic-pituitary-adrenocortical (HPA) axis and sympathetic adrenomedullary (SAM) system activity, during the Strange Situation (SS) procedure in a sample of more than 100 healthy infants, aged 12 to 18 months. Results: Individual differences in alpha amylase response to separation were predicted by security of attachment in interaction with 5-HTTLPR and GABRA6 genetic polymorphisms, whereas alpha amylase basal levels were predicted by COMT x attachment interaction. No significant effect of attachment, genetics and their interaction on cortisol activity emerged. Conclusions: These results help to disentangle the role played by both genetic and environmental factors in determining individual differences in stress response in infancy. The results also shed light on the suggestion that HPA and SAM systems are likely to have different characteristic responses to stress.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc7fb01c693d98dc40daa6d2bd7599d https://pubmed.ncbi.nlm.nih.gov/19686331 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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