Antithrombotic effects of YM-60828 in three thrombosis models in guinea pigs
| Autor: | Fukushi Hirayama, Yuta Taniuchi, Kazuo Sato, Masato Ichihara, Hiroyuki Koshio, Yuzo Matsumoto, Nami Hisamichi, Tomihisa Kawasaki |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Bleeding Time medicine.drug_mechanism_of_action medicine.drug_class Factor Xa Inhibitor Antithrombin III Guinea Pigs Naphthalenes Prolonged bleeding time Arteriovenous Shunt Surgical Fibrinolytic Agents Piperidines Bleeding time Internal medicine Antithrombotic medicine Animals Carotid Artery Thrombosis Vein Pharmacology medicine.diagnostic_test business.industry Anticoagulant Thrombosis Thrombophlebitis medicine.disease Venous thrombosis Disease Models Animal medicine.anatomical_structure Anesthesia Cardiology business Carotid Artery Internal Factor Xa Inhibitors |
| Zdroj: | European journal of pharmacology. 350(1) |
| ISSN: | 0014-2999 |
| Popis: | The antithrombotic effects of a novel factor Xa inhibitor, YM-60828 ([N-[4-[(1-acetimidoyl-4-piperidyl)oxy]phenyl]-N-[(7-amidino-2-nap hthyl)methyl]sulfamoyl]acetic acid dihydrochloride), in three thrombosis models in guinea pigs were studied in comparison with its effect on bleeding time. The antithrombotic effects of YM-60828 were most pronounced in the venous thrombosis and the arterio-venous shunt models but YM-60828 showed 10-fold weaker effects in the carotid thrombosis model. However, YM-60828 prolonged bleeding time at a much higher dose than that required in all thrombosis models. In conclusion, YM-60828 exerted its antithrombotic effects without prolonging bleeding time in all thrombosis models and may be of clinical value not only in venous thrombosis but also in arterial thrombosis. |
| Databáze: | OpenAIRE |
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