Cloning novel immune-type inhibitory receptors from the rainbow trout, Oncorhynchus mykiss
| Autor: | Tatsuya Ota, Krista M. Nichols, Gail Mueller, Jeffrey A. Yoder, Gary W. Litman, Gary H. Thorgaard, Sandra S. Ristow |
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| Rok vydání: | 2002 |
| Předmět: |
Cloning
Genetics Sequence Homology Amino Acid Gene map Phylogenetic tree Lineage (evolution) Molecular Sequence Data Immunology Chromosome Mapping Immunoglobulin domain Biology Species Specificity Oncorhynchus mykiss Animals Rainbow trout Amino Acid Sequence RNA Messenger Cloning Molecular Receptors Immunologic Receptor Gene Phylogeny |
| Zdroj: | Immunogenetics. 54:662-670 |
| ISSN: | 1432-1211 0093-7711 |
| DOI: | 10.1007/s00251-002-0511-3 |
| Popis: | Novel immune-type receptor ( NITR) genes that encode two extracellular immunoglobulin domains and cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs) have been described previously in three lineages of bony fish. In the current study, four ITIM-containing NITR cDNAs are identified in the rainbow trout ( Oncorhynchus mykiss), and their expression patterns and genomic complexity are characterized. The ITIM-containing NITR2 gene maps 1.3 cM from an ITIM-containing C-type lectin receptor ( TCL-2) on linkage group XXI. A comprehensive, phylogenetic analysis of NITRs from rainbow trout and three other major lineages of bony fish defines conserved families of NITRs and suggests an ancient lineage of distinct groups of genes. Several probable scenarios that explain the origins of variant forms of NITRs are described. |
| Databáze: | OpenAIRE |
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