Pharmacokinetic Study of Azithromycin with Fluconazole and Cotrimoxazole (Trimethoprim-Sulfamethoxazole) in Healthy Volunteers
| Autor: | George H Foulds, Guy W. Amsden, Kamlesh M. Thakker |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.drug_class Sulfamethoxazole Antibiotics General Medicine Pharmacology bacterial infections and mycoses Azithromycin Trimethoprim Macrolide Antibiotics Pharmacotherapy Pharmacokinetics Internal medicine Medicine Pharmacology (medical) business Fluconazole medicine.drug |
| Zdroj: | Clinical Drug Investigation. 20:135-142 |
| ISSN: | 1173-2563 |
| DOI: | 10.2165/00044011-200020020-00008 |
| Popis: | Background: Azithromycin, fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole; TMP/SMX) are all agents that are utilised for the treatment and/or prophylaxis of opportunistic infections in patients with AIDS. Objective: To characterise the potential for an interaction when azithromycin is coadministered with cotrimoxazole or with fluconazole. Design: Two separate nonblind randomised studies were conducted in healthy volunteers. During the fluconazole study the potential for fluconazole to adversely affect the pharmacokinetics of azithromycin was also studied. Participants: 24 (cotrimoxazole) and 18 (fluconazole) healthy male and female volunteers. Results: The results of both studies indicated that neither the peak concentrations of nor the exposures (area under the concentration-time curve) to the test drugs were changed when azithromycin was coadministered. In addition, fluconazole did not significantly alter the pharmacokinetic parameters of azithromycin. Conclusions: Azithromycin does not alter the bioavailability of either cotrimoxazole or fluconazole. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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