Acute exacerbation of idiopathic pulmonary fibrosis: usual interstitial pneumonitis vs. possible usual interstitial pneumonitis pattern
| Autor: | Yonglong Xiao, Jian Sheng, Mengshu Cao, Yang Wang, Tian-Zhen Wang, Xiaohua Qiu, Dongmei Wang, Hourong Cai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Exacerbation lcsh:Medicine Idiopathic pulmonary fibrosis Usual interstitial pneumonitis Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Pulmonary fibrosis Humans Medicine Proportional Hazards Models Retrospective Studies business.industry Proportional hazards model lcsh:R Retrospective cohort study Original Articles General Medicine respiratory system Prognosis medicine.disease Respiratory Function Tests respiratory tract diseases Acute exacerbation 030220 oncology & carcinogenesis Acute Disease Multivariate Analysis Female business 030217 neurology & neurosurgery |
| Zdroj: | Chinese Medical Journal, Vol 132, Iss 18, Pp 2177-2184 (2019) Chinese Medical Journal |
| ISSN: | 2542-5641 0366-6999 |
| DOI: | 10.1097/CM9.0000000000000422 |
| Popis: | Background:. The prognosis of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is very poor with a high mortality. The aim of this study was to describe the clinical features and survival of patients with AE-IPF with usual pulmonary fibrosis (UIP) and possible UIP (P-UIP) pattern on chest high resolution computed tomography (HRCT). Methods:. This retrospective study included 107 patients with AE-IPF admitted to Nanjing Drum Tower Hospital from January 2010 to December 2016. The subjects were divided into UIP (n = 86) and P-UIP group (n = 21) based on chest HRCT. Continuous variables were analyzed using Student's t test or Mann-Whitney U test. Categorical variables were analyzed using χ2 test. Log-rank test was used for the survival analysis. Cox proportional models evaluated the risk factors for AE occurrence and survival. Results:. The male, older patients, previous N-acetylcysteine use, elevated white blood cell (WBC) counts, and microbiology infection were more common in the UIP group than the P-UIP group (χ2 = 13.567, P |
| Databáze: | OpenAIRE |
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