Central noradrenaline transporter availability is linked with HPA axis responsiveness and copeptin in human obesity and non-obese controls
| Autor: | Marianne Patt, Osama Sabri, Matthias Blüher, Swen Hesse, Elisa Schmidt, Franziska Zientek, Florian Then Bergh, Georg-Alexander Becker, Christian Schinke, Philipp Meyer, Yu-Shin Ding, Jürgen Kratzsch, Johannes Orthgieß, Muriel Stoppe, Julia Luthardt, Michael Rullmann, Klara Meyer |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Hypothalamo-Hypophyseal System Hydrocortisone Physiology Corticotropin-Releasing Hormone Pituitary-Adrenal System Noradrenaline Transporter Dexamethasone 03 medical and health sciences Behavioral Neuroscience Norepinephrine 0302 clinical medicine Copeptin Non obese Adrenocorticotropic Hormone Internal medicine Medicine Humans Obesity Human obesity Norepinephrine Plasma Membrane Transport Proteins Endocrine and Autonomic Systems business.industry Glycopeptides Brain medicine.disease 030227 psychiatry Arginine Vasopressin Psychiatry and Mental health Neuropsychology and Physiological Psychology Endocrinology Female business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Stress (Amsterdam, Netherlands). 22(1) |
| ISSN: | 1607-8888 |
| Popis: | The central noradrenaline (NA) stress-response network co-mediates hypothalamic-pituitary-adrenal (HPA) axis activation and arginine-vasopressin (AVP) release. Dysregulation of these systems contributes to stress-related diseases such as human obesity, but their interrelation remains unclear. The study was aimed to test for the first time in vivo whether central noradrenergic activity quantitatively indexed by the availability of the presynaptic NA transporter (NAT) is associated with HPA axis responsiveness as measured with the combined dexamethasone suppression/corticotropin releasing hormone stimulation (dex/CRH) test and copeptin as a surrogate marker of the serum AVP tone in highly obese, otherwise, healthy individuals compared to age- and sex-matched non-obese, healthy controls. In order to assess central NAT availability, positron emission tomography (PET) was applied using the NAT-selective radiotracer S,S-[ |
| Databáze: | OpenAIRE |
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