Central noradrenaline transporter availability is linked with HPA axis responsiveness and copeptin in human obesity and non-obese controls

Autor: Marianne Patt, Osama Sabri, Matthias Blüher, Swen Hesse, Elisa Schmidt, Franziska Zientek, Florian Then Bergh, Georg-Alexander Becker, Christian Schinke, Philipp Meyer, Yu-Shin Ding, Jürgen Kratzsch, Johannes Orthgieß, Muriel Stoppe, Julia Luthardt, Michael Rullmann, Klara Meyer
Rok vydání: 2018
Předmět:
Zdroj: Stress (Amsterdam, Netherlands). 22(1)
ISSN: 1607-8888
Popis: The central noradrenaline (NA) stress-response network co-mediates hypothalamic-pituitary-adrenal (HPA) axis activation and arginine-vasopressin (AVP) release. Dysregulation of these systems contributes to stress-related diseases such as human obesity, but their interrelation remains unclear. The study was aimed to test for the first time in vivo whether central noradrenergic activity quantitatively indexed by the availability of the presynaptic NA transporter (NAT) is associated with HPA axis responsiveness as measured with the combined dexamethasone suppression/corticotropin releasing hormone stimulation (dex/CRH) test and copeptin as a surrogate marker of the serum AVP tone in highly obese, otherwise, healthy individuals compared to age- and sex-matched non-obese, healthy controls. In order to assess central NAT availability, positron emission tomography (PET) was applied using the NAT-selective radiotracer S,S-[
Databáze: OpenAIRE