MLKL: Functions beyond serving as the Executioner of Necroptosis
| Autor: | Jin Hou, Minchun Huang, Xiaojun Yang, Chaoning Zhan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Programmed cell death Cardiolipins Necroptosis Regulator necroptosis Medicine (miscellaneous) therapeutic target Apoptosis Review Biology Extracellular Traps Mixed Lineage Kinase 03 medical and health sciences 0302 clinical medicine Neoplasms inhibitors Regulated cell death Autophagy Pyroptosis Humans structure Regulated Cell Death Pharmacology Toxicology and Pharmaceutics (miscellaneous) Phospholipids Inflammation Necroptosis signaling Effector Multiple pathologies 030104 developmental biology Gene Expression Regulation 030220 oncology & carcinogenesis Protein Kinases Neuroscience MLKL |
| Zdroj: | Theranostics |
| ISSN: | 1838-7640 |
| DOI: | 10.7150/thno.54072 |
| Popis: | Recently, necroptosis, as a programmed cell death pathway, has drawn much attention as it has been implicated in multiple pathologies, especially in the field of inflammatory diseases. Pseudokinase mixed lineage kinase domain-like protein (MLKL) serves as a terminal-known obligate effector in the process of necroptosis. To date, the majority of research on MLKL has focused on its role in necroptosis, and the prevailing view has been that the sole function of MLKL is to mediate necroptosis. However, increasing evidence indicates that MLKL can serve as a regulator of many diseases via its non-necroptotic functions. These functions of MLKL shed light on its functional complexity and diversity. In this review, we briefly introduce the current state of knowledge regarding the structure of MLKL, necroptosis signaling, as well as cross-linkages among necroptosis and other regulated cell death pathways, and we particularly highlight recent progress related to newly identified functions and inhibitors of MLKL. These discussions promote a better understanding of the role of MLKL in diseases, which will foster efforts to pharmacologically target this molecule in clinical treatments. |
| Databáze: | OpenAIRE |
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