Intestinal Epithelial Cell Proteome in IL-10 Deficient Mice and IL-10 Receptor Reconstituted Epithelial Cells: Impact on Chronic Inflammation
| Autor: | Dirk Haller, and Anna Shkoda, Tanja Werner |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Proteomics
Galectin 3 Transgene Apoptosis Mice Transgenic Inflammation Biology Endoplasmic Reticulum digestive system Biochemistry Mice Enterococcus faecalis medicine Animals Electrophoresis Gel Two-Dimensional Receptors Interleukin-10 Intestinal Mucosa Receptor Endoplasmic reticulum Epithelial Cells General Chemistry Colitis Epithelium Interleukin-10 Cell biology Interleukin 10 medicine.anatomical_structure Proteome medicine.symptom |
| Zdroj: | Journal of Proteome Research. 6:3691-3704 |
| ISSN: | 1535-3907 1535-3893 |
| DOI: | 10.1021/pr070222x |
| Popis: | The interaction of nonpathogenic enteric bacteria with intestinal epithelial cells (IEC) in the absence of host-derived Interleukin 10 (IL-10) may contribute to the development of chronic inflammation. Functional proteome analysis of primary IEC from Enterococcus faecalis-monoassociated WT and IL-10-/- mice as well as IL-10 receptor reconstituted IEC revealed expression changes of proteins that are involved in endoplasmic reticulum stress, energy metabolism, and apoptosis, suggesting a protective role for IL-10 at the epithelial cell level. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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