The association of the HLA in patients with schizophrenia, schizoaffective disorder, and in their biological relatives
| Autor: | Sandra Odebrecht Vargas Nunes, Tiemi Matsuo, Maria Angelica Ehara Watanabe, E.N. Itano, S.D. Borelli |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Employment Male medicine.medical_specialty Genotype Schizoaffective disorder Human leukocyte antigen HLA Antigens medicine Humans Family In patient Educational achievement Psychiatry Association (psychology) Biological Psychiatry Hla genotype HLA-DR Antigens Middle Aged Achievement medicine.disease Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Mood Psychotic Disorders Schizophrenia Female Psychology |
| Zdroj: | Schizophrenia Research. 76:195-198 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2005.02.005 |
| Popis: | To determine the association of the HLA in 50 patients with schizophrenia, schizoaffective disorder, 48 healthy controls, 41 biological relatives without psychiatric disease, and 48 biological relatives with mood disorder, the HLA genotype at the class I and class II were determined. The subjects were interviewed by structured diagnostic criteria categorized according to DSM-IV, axis I, (SCID-IV). Significant positive association was found with HLA-B*15 in patients, family with humor disorder and without mental disorder ( p = 0.003) and negative association of the HLA-B*35 in relatives without psychiatric disease ( p = 0.03). The HLA-B*15 frequency was significantly increased in a subgroup of patients with age at onset in the early 20s, lower educational achievement, occupational disability, chronically ill, more paranoid type. These findings suggest the existence of some involvement of an immunogenetic mechanism in a subgroup of schizophrenic, schizoaffective patients, and biological relatives. |
| Databáze: | OpenAIRE |
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