Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage

Autor: Roberta Fiume, Irene Faenza, Antonio Enrico Zaurito, Nullin Divecha, Shidqiyyah Abdul-Hamid, Alessandro Poli
Přispěvatelé: Poli A., Zaurito A.E., Abdul-Hamid S., Fiume R., Faenza I., Divecha N.
Jazyk: angličtina
Rok vydání: 2019
Předmět:
PI5P4K/PIP4K
Myotubularin
Phosphatidylinositol Phosphates
Receptors
Cytoplasmic and Nuclear
Review
PI5P
Catalysis
Chromatin remodeling
lcsh:Chemistry
Inorganic Chemistry
PIKFYVE
chemistry.chemical_compound
Stress
Physiological
Phosphatase
Animals
Humans
Nucleu
Phosphatidylinositol
Physical and Theoretical Chemistry
Nuclear protein
phosphatases
Cell Nucleu
lcsh:QH301-705.5
Molecular Biology
Phosphatidylinositol 5-phosphate
Spectroscopy
Nuclear Protein
Cell Nucleus
Animal
Phosphatidylinositol Phosphate
Chemistry
Kinase
Organic Chemistry
nucleus
Nuclear Proteins
General Medicine
Lipid Metabolism
Computer Science Applications
Cell biology
myotubularin
Phosphotransferases (Alcohol Group Acceptor)
lcsh:Biology (General)
lcsh:QD1-999
PIKFyve
Reactive Oxygen Specie
Reactive Oxygen Species
Human
Signal Transduction
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2080 (2019)
ISSN: 1422-0067
Popis: Phosphatidylinositol (PI)-related signaling plays a pivotal role in many cellular aspects, including survival, cell proliferation, differentiation, DNA damage, and trafficking. PI is the core of a network of proteins represented by kinases, phosphatases, and lipases which are able to add, remove or hydrolyze PI, leading to different phosphoinositide products. Among the seven known phosphoinositides, phosphatidylinositol 5 phosphate (PI5P) was the last to be discovered. PI5P presence in cells is very low compared to other PIs. However, much evidence collected throughout the years has described the role of this mono-phosphoinositide in cell cycles, stress response, T-cell activation, and chromatin remodeling. Interestingly, PI5P has been found in different cellular compartments, including the nucleus. Here, we will review the nuclear role of PI5P, describing how it is synthesized and regulated, and how changes in the levels of this rare phosphoinositide can lead to different nuclear outputs.
Databáze: OpenAIRE
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