Chronic effects of fumonisin B1 on ducks
| Autor: | P. Guerre, A. Auvergne, G. Benard, S.T. Tran, R. Babilé, D. Tardieu, Jean-Denis Bailly |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Spleen Kidney Fumonisins chemistry.chemical_compound Sphingosine Internal medicine Lactate dehydrogenase medicine Animals Gizzard Fumonisin B1 L-Lactate Dehydrogenase Cholesterol Body Weight Alanine Transaminase General Medicine Blood Proteins Organ Size Alkaline Phosphatase Diet medicine.anatomical_structure Endocrinology Ducks chemistry Alkaline phosphatase Animal Science and Zoology |
| Zdroj: | Poultry science. 84(1) |
| ISSN: | 0032-5791 |
| Popis: | Partially purified fumonisin B1 (FB1) was orally administrated for 77 d to 5 groups of 8 mule ducks starting at 7 d of age; the concentrations corresponded to 5 diets containing 0, 2, 8, 32, and 128 mg of FB1/kg of feed. No mortality was observed, and no effects on feed consumption and body weight gain were observed at the end of the treatment period. But, surprisingly, FB1 ingested at 32 and 128 mg/kg led to decreased body weight from d 28 to 63 and from d 7 to 63, respectively. FB1 had no effect on the relative weight of heart and breast muscle, whereas a significant increases in the relative weights of gizzard, spleen, and liver were measured in ducks receiving 32 and 128 mg of FB1/kg of feed without evidence of detectable microscopic modification of these organs. FB1 had no significant effect of the serum aspartate aminotransferase and gamma-glutamyltransferase levels but increased serum total protein, cholesterol, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase levels when 128 mg of FB1/kg of feed was given. Serum, liver, and kidney sphinganine to sphingosine ratio was significantly increased in ducks fed 8 to 128 mg of FB1/kg of feed. The biggest increase was observed in kidneys, suggesting that this organ is the most sensitive to detect FB1-induced disruption of sphingolipid metabolism. |
| Databáze: | OpenAIRE |
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