Copper-mediated direct thiolation of aryl C–H bonds with disulfides
| Autor: | Hexin Xie, Li-Li Zhang, Ya-Fei Ji, Chengcai Xia, Ke-Zuan Deng, Ye-Feng Chen, Xiao-Bo Xu |
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| Rok vydání: | 2019 |
| Předmět: |
Steric effects
chemistry.chemical_classification 010405 organic chemistry Aryl Organic Chemistry Copper mediated 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Amine gas treating Physical and Theoretical Chemistry Alkyl |
| Zdroj: | Organic & Biomolecular Chemistry. 17:7055-7065 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c9ob01255a |
| Popis: | An efficient copper-mediated ortho-C(sp2)-H thiolation of aromatic amides directed by a novel directing group [4-chloro-2-(1H-pyrazol-1-yl)phenyl]amine has been developed without the need of other additives or oxidants, allowing for an increased usefulness. With the high compatibility of sterically demanding substrates, this reaction is scalable and can tolerate a wide scope of functional groups to provide alkyl and aryl thioethers in good to excellent yields (up to 93%). Furthermore, the protocol has been successfully implemented for the selenylation as well. |
| Databáze: | OpenAIRE |
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