Facilitating Cytokine-Mediated Cancer Cell Death by Proteobacterial N-Acylhomoserine Lactones
| Autor: | Amanda L. Garner, Kim D. Janda, Richard J. Ulevitch, Jing Yu, Vladimir V. Kravchenko, John C. Mathison, Irina P. Gileva, Alim S. Seit-Nebi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_treatment
Apoptosis Inflammation Acyl-Butyrolactones Biochemistry Article TNF-Related Apoptosis-Inducing Ligand Cell Line Tumor Neoplasms medicine Humans biology NF-kappa B food and beverages General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification Cell biology Immunosurveillance Cytokine Pseudomonas aeruginosa Cancer cell Cytokines Molecular Medicine Tumor necrosis factor alpha medicine.symptom Signal transduction Bacteria Signal Transduction |
| Zdroj: | ACS Chemical Biology. 8:1117-1120 |
| ISSN: | 1554-8937 1554-8929 |
| Popis: | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in cancer cells over normal cells; however, tumor cells may develop TRAIL resistance. Here, we demonstrate that this resistance can be overcome in the presence of bacterial acylhomoserine lactones (AHLs) or AHL-producing bacteria through the combined effect of TRAIL-induced apoptosis and AHL-mediated inhibition of inflammation regulated by NF-κB signaling. This discovery unveils a previously unrecognized symbiotic link between bacteria and host immunosurveillance. |
| Databáze: | OpenAIRE |
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