Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons
| Autor: | Merryn Brettle, Lars M. Ittner, Alexandra K. Suchowerska, Thomas Fath, Sook Wern Chua |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Dendritic spine
Dendritic Spines Primary Cell Culture Hippocampus macromolecular substances Hippocampal formation medicine.disease_cause Profilins Protein Aggregates medicine Animals Humans Amyotrophic lateral sclerosis Neurons Mutation biology General Neuroscience Amyotrophic Lateral Sclerosis Dendrites Motor neuron Actin cytoskeleton medicine.disease Cell biology Mice Inbred C57BL medicine.anatomical_structure HEK293 Cells Profilin biology.protein Neuroscience |
| Zdroj: | Neuroscience letters. 609 |
| ISSN: | 1872-7972 |
| Popis: | Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease and familial ALS accounts for 10% of cases. The identification of familial ALS mutations in the actin-binding protein profilin 1 directly implicates actin dynamics and regulation in the pathogenesis of ALS. The mechanism by which these mutations cause ALS is unknown. In this study we show that expression of the ALS-associated actin-binding deficient mutant of PFN1 (PFN1(C71G)) results in increased dendritic arborisation and spine formation, and cytoplasmic inclusions in cultured mouse hippocampal neurons. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect