Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases
| Autor: | Eric M. Shooter, Junji Yamauchi, Jonah R. Chan |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
rho GTP-Binding Proteins
RHOA Schwann cell RAC1 Receptors Nerve Growth Factor CDC42 Neurotrophin-3 Receptor Nerve Growth Factor Mice Neurotrophin 3 Cell Movement Neurotrophic factors medicine Animals Receptor trkB Receptor trkC Nerve Growth Factors Proto-Oncogene Proteins c-vav Cells Cultured Oncogene Proteins Multidisciplinary biology Brain-Derived Neurotrophic Factor Schwann cell migration Biological Sciences Rats Cell biology Enzyme Activation src-Family Kinases medicine.anatomical_structure nervous system biology.protein Schwann Cells rhoA GTP-Binding Protein Signal Transduction Neurotrophin |
| Zdroj: | Proceedings of the National Academy of Sciences. 101:8774-8779 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.0402795101 |
| Popis: | Neurotrophins are recognized widely as essential factors in the developing nervous system. Previously, we demonstrated that neurotrophin 3 activation of TrkC inhibits Schwann cell myelination and enhances the migration of primary Schwann cells through the signaling pathway regulated by the Rho GTPases Rac1 and Cdc42. Here, we show that neurotrophins activate divergent signaling pathways to promote or inhibit Schwann cell migration. Endogenous brain-derived neurotrophic factor acting through p75 NTR inhibits Schwann cell migration dramatically by Src kinase-dependent activation of the guanine-nucleotide exchange factor Vav2 and RhoA. Together, these results suggest that neurotrophins and their receptors differentially regulate Schwann cell migration through the signaling pathways that depend on Rho GTPases. |
| Databáze: | OpenAIRE |
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