一次治療でセツキシマブ不耐となった後，三次治療での再使用により奏功した進行大腸癌の一例
| Autor: | Tatsuya Morikawa, Yoshiko Mori, Takahito Yagi, Yoshitaka Kondo, Nobuhito Kubota, Toshiyoshi Fujiwara, Futoshi Uno, Ryo Inada, Yu Sadamori, Takeshi Nagasaka, Yuzo Umeda |
|---|---|
| Jazyk: | japonština |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty Cetuximab Bevacizumab medicine.diagnostic_test Colorectal cancer business.industry 大腸癌（colorectal cancer） Colonoscopy medicine.disease medicine.disease_cause digestive system diseases Irinotecan Regimen セツキシマブ再投与（cetuximab rechallenge） 化学療法（chemotherapy） Internal medicine medicine FOLFIRI Regimen Radiology KRAS business neoplasms medicine.drug |
| Zdroj: | 岡山医学会雑誌. 125(1):51-55 |
| ISSN: | 0030-1558 |
| Popis: | A 55-year-old man who had been diagnosed with rectal cancer with multiple liver metastases and lymph node metastases on colonoscopy and computed tomography (CT) was referred to Okayama University Hospital for treatment. Based on the diagnosis of non-curative rectal cancer, we planned to perform systematic chemotherapy after surgical resection. We performed a low anterior resection of a 36×35 mm upper rectal moderately differentiated adenocarcinoma with wil-type KRAS. After the resection, a FOLFIRI regimen with cetuximab was given as the firstline chemotherapy. Although metastatic lesions in the liver showed shrinkage, we decided to switch regimens because of intolerable adverse events. A modified FOLFOX6 regimen with bevacizumab was administered as the second-line treatment. There were no signs of disease progression until eight months later, when positron emission tomography (PET)/CT scans revealed that the new metastatic lesions appeared. As the third-line treatment, an irinotecan with cetuximab regimen was administered, leading to a good response for over 12 months. We experienced a successful rechallenge with cetuximab for a case with metastatic rectal cancer. For patients with wild-type KRAS colorectal cancer, rechallenge with cetuximab-based chemotherapy can be an effective therapeutic option. 症例報告 岡山医学会雑誌 第125巻 April 2013, pp. 51-55 |
| Databáze: | OpenAIRE |
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