Metamaterial-enhanced vibrational absorption spectroscopy for the detection of protein molecules
| Autor: | Lam D. Vu, Toshihide Nabatame, YoungPak Lee, Luu H. Dang, Thang Duy Dao, Chung Vu Hoang, Tadaaki Nagao, Akihiko Ohi, Tung S. Bui |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
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Silver Materials science Absorption spectroscopy Terahertz radiation 02 engineering and technology Vibration 01 natural sciences Article Rhodamine 6G chemistry.chemical_compound 0103 physical sciences Benzothiazoles 010306 general physics Spectroscopy Absorption (electromagnetic radiation) Plasmon Terahertz Spectroscopy chemistry.chemical_classification Multidisciplinary Rhodamines business.industry Biomolecule Proteins Serum Albumin Bovine Carbocyanines 021001 nanoscience & nanotechnology chemistry Molecular vibration Optoelectronics 0210 nano-technology business |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | From visible to mid-infrared frequencies, molecular sensing has been a major successful application of plasmonics because of the enormous enhancement of the surface electromagnetic nearfield associated with the induced collective motion of surface free carriers excited by the probe light. However, in the lower-energy terahertz (THz) region, sensing by detecting molecular vibrations is still challenging because of low sensitivity, complicated spectral features, and relatively little accumulated knowledge of molecules. Here, we report the use of a micron-scale thin-slab metamaterial (MM) architecture, which functions as an amplifier for enhancing the absorption signal of the THz vibration of an ultrathin adsorbed layer of large organic molecules. We examined bovine serum albumin (BSA) as a prototype large protein molecule and Rhodamine 6G (Rh6G) and 3,3′-diethylthiatricarbocyanine iodide (DTTCI) as examples of small molecules. Among them, our MM significantly magnified only the signal strength of bulky BSA. On the other hand, DTTCI and Rh6G are inactive, as they lack low-frequency vibrational modes in this frequency region. The results obtained here clearly demonstrate the promise of MM-enhanced absorption spectroscopy in the THz region for detection and structural monitoring of large biomolecules such as proteins or pathogenic enzymes. |
| Databáze: | OpenAIRE |
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